GYS2 and TNFRSF1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GYS2	TNFRSF1A
Description		glycogen synthase 2	TNF receptor superfamily member 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell Cortex Cortical Actin Cytoskeleton	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft
	Molecular Function	Catalytic Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Transferase Activity Glycosyltransferase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity Tumor Necrosis Factor Binding
	Biological Process	Glycogen Biosynthetic Process Response To Glucose	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Transcription By RNA Polymerase II Prostaglandin Metabolic Process Apoptotic Process Defense Response Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Non-canonical NF-kappaB Signal Transduction Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Regulation Of Membrane Lipid Metabolic Process
Pathways		Glycogen synthesis Glycogen storage disease type 0 (liver GYS2) Glycogen storage disease type IV (GBE1)	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling
Drugs			6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS		Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Fasting insulin ( 34059833) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil count ( 32888494) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 27386562 24076602 31604244 21833088 19525953) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 21399635 28425483 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: MDM2 TNFRSF1A TP53	67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		2998	7132
HPRD ID		00722	01861
Ensembl ID		ENSG00000111713	ENSG00000067182
Uniprot IDs		P54840	J9PH39 P19438
PDB IDs			1EXT 1FT4 1ICH 1NCF 1TNR 7K7A 7KP7 7KP8 7KPB 8P6Q
Enriched GO Terms of Interacting Partners?		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Cellular Response To Antibiotic Response To UV-C Cellular Response To Gamma Radiation Disordered Domain Specific Binding Heart Valve Development Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Gamma Radiation Tumor Necrosis Factor-mediated Signaling Pathway Transcription Repressor Complex Cardiac Septum Morphogenesis P53 Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Amide Metabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To UV DNA Damage Response Signal Transduction By P53 Class Mediator Cellular Response To Light Stimulus Apoptotic Process Response To Formaldehyde Programmed Cell Death Cellular Response To Vitamin B1 Cell Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Oxygen Levels Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Protein Localization To Nucleus Regulation Of Cell Cycle G1/S Phase Transition Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cytosol Programmed Cell Death Cell Death Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor Receptor Binding Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Stress Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway Kinase Activity Positive Regulation Of Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Activation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation
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