GYS2 and TNFRSF1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GYS2	TNFRSF1A
Gene Name		glycogen synthase 2 (liver)	tumor necrosis factor receptor superfamily, member 1A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell Cortex Cortical Actin Cytoskeleton Ectoplasm	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse
	Molecular Function	Glycogen (starch) Synthase Activity Protein Homodimerization Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Pathogenesis Response To Glucose Small Molecule Metabolic Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway
Pathways		Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs			6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		2 interactors: GYG2 TNFRSF1A	60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		2998	7132
HPRD ID		00722	01861
Ensembl ID		ENSG00000111713	ENSG00000067182
Uniprot IDs		P54840	J9PH39 P19438
PDB IDs			1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Glycogen Catabolic Process Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Estradiol Stimulus Polysaccharide Catabolic Process Glycogen Biosynthetic Process Cellular Response To Estrogen Stimulus Prostaglandin Metabolic Process Cellular Carbohydrate Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Cellular Polysaccharide Biosynthetic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Polysaccharide Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tumor Necrosis Factor Production Glycogen Metabolic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Neuron Death Tetrapyrrole Metabolic Process Polysaccharide Metabolic Process Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Icosanoid Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Tumor Necrosis Factor Regulation Of Interleukin-6 Production Unsaturated Fatty Acid Metabolic Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Response To Amino Acid Small Molecule Metabolic Process Response To Estradiol Response To Tumor Necrosis Factor Positive Regulation Of Angiogenesis Protein Heterooligomerization Energy Reserve Metabolic Process Response To Ethanol Glucose Metabolic Process Response To Alkaloid Carbohydrate Biosynthetic Process Carbohydrate Catabolic Process	Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?			casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Difference) ?			casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Intersection) ?