GYS2

Description		glycogen synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell Cortex Cortical Actin Cytoskeleton
	Molecular Function	Catalytic Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Transferase Activity Glycosyltransferase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate
	Biological Process	Glycogen Biosynthetic Process Response To Glucose
Pathways		Glycogen synthesis Glycogen storage disease type 0 (liver GYS2) Glycogen storage disease type IV (GBE1)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Fasting insulin ( 34059833) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		3 interacting genes: MDM2 TNFRSF1A TP53
Entrez ID		2998
HPRD ID		00722
Ensembl ID		ENSG00000111713
Uniprot IDs		P54840
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Cellular Response To Antibiotic Response To UV-C Cellular Response To Gamma Radiation Disordered Domain Specific Binding Heart Valve Development Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Gamma Radiation Tumor Necrosis Factor-mediated Signaling Pathway Transcription Repressor Complex Cardiac Septum Morphogenesis P53 Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Amide Metabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To UV DNA Damage Response Signal Transduction By P53 Class Mediator Cellular Response To Light Stimulus Apoptotic Process Response To Formaldehyde Programmed Cell Death Cellular Response To Vitamin B1 Cell Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Oxygen Levels Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Protein Localization To Nucleus Regulation Of Cell Cycle G1/S Phase Transition Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Intrinsic Apoptotic Signaling Pathway
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