GUCY2C and PDZD3

Number of citations of the paper that reports this interaction (PMID 11950846)
17

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		GUCY2C	PDZD3
Gene Name		guanylate cyclase 2C	PDZ domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Cytosol Brush Border Subapical Complex Apical Part Of Cell
	Molecular Function	Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Proliferation	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GUCA2A PDZD3 SRC	17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		2984	79849
HPRD ID		07529	06191
Ensembl ID		ENSG00000070019	ENSG00000172367
Uniprot IDs		P25092	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?		Regulation Of CGMP Biosynthetic Process Regulation Of CGMP Metabolic Process Regulation Of Cyclase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of CGMP Biosynthetic Process Cellular Response To Progesterone Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Regulation Of Podosome Assembly Regulation Of Caveolin-mediated Endocytosis Regulation Of Catalytic Activity Osteoclast Development Negative Regulation Of Protein Oligomerization CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Regulation Of Integrin Activation Regulation Of Early Endosome To Late Endosome Transport Transcytosis Signal Complex Assembly Stress Fiber Assembly Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Uterus Development Positive Regulation Of CGMP Biosynthetic Process Intracellular Estrogen Receptor Signaling Pathway Regulation Of Anoikis Response To Acidic PH Regulation Of Mitochondrial Depolarization Positive Regulation Of CGMP Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Lyase Activity Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Catalytic Activity Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Protein Oligomerization Activation Of Protein Kinase B Activity	Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis
Tagcloud ?		abrogation antigens autoimmunity cd4 cd8 creates cyclase durable elimination epitopes foreign formidable guanylyl immunotherapeutics incorporating inefficacy offered pools preservation presumably prevailing reconstituted reflects revealing tolerance trp2 unbiased underlies vaccines
Tagcloud (Difference) ?		abrogation antigens autoimmunity cd4 cd8 creates cyclase durable elimination epitopes foreign formidable guanylyl immunotherapeutics incorporating inefficacy offered pools preservation presumably prevailing reconstituted reflects revealing tolerance trp2 unbiased underlies vaccines
Tagcloud (Intersection) ?