GUCY2C and GUCA2A

Number of citations of the paper that reports this interaction (PubMedID 10601865)
0

Data Source:
HPRD (in vitro, in vivo)

		GUCY2C	GUCA2A
Description		guanylate cyclase 2C	guanylate cyclase activator 2A
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Extracellular Region
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding Lyase Activity Phosphorus-oxygen Lyase Activity	Hormone Activity Protein Binding Guanylate Cyclase Activator Activity
	Biological Process	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Cyclic Nucleotide Biosynthetic Process Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Population Proliferation	Signal Transduction
Pathways		Digestion Intestinal infectious diseases	Digestion
Drugs		Linaclotide
Diseases
GWAS
Interacting Genes		3 interacting genes: GUCA2A NHERF4 SRC	15 interacting genes: ASPH FFAR2 GJA8 GOLM1 GUCY2C NEMP1 SGTA SLC34A2 TMEM179B TMEM237 TMEM31 TMEM86B TRAM1 UBQLN1 UBQLN2
Entrez ID		2984	2980
HPRD ID		07529	00767
Ensembl ID		ENSG00000070019	ENSG00000197273
Uniprot IDs		P25092	Q02747
PDB IDs		8FX4 8GHO 8GHP	1GNA 1GNB 1O8R
Enriched GO Terms of Interacting Partners?		Guanylate Cyclase Activator Activity Bone Resorption Angiotensin-activated Signaling Pathway Signaling Receptor Binding Negative Regulation Of Hippo Signaling Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Caveolin-mediated Endocytosis Connexin Binding Regulation Of Lamellipodium Morphogenesis Regulation Of Integrin Activation Positive Regulation Of Dephosphorylation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Maturation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Signal Complex Assembly Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Mitochondrial Depolarization Uterus Development Negative Regulation Of Focal Adhesion Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Neutrophil Activation Response To Platelet-derived Growth Factor Endolysosomal Toll-like Receptor Signaling Pathway Contractile Actin Filament Bundle Assembly Regulation Of Dephosphorylation Stress Fiber Assembly Progesterone Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phospholipase Binding Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Anoikis Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Glycolytic Process Neutrophil Activation Involved In Immune Response	Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Protein Insertion Into ER Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Response To Endoplasmic Reticulum Stress Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Protein Targeting To Membrane TRC Complex Protein Insertion Into Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Autophagosome Assembly
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