GUCY2C and GUCA2A

Number of citations of the paper that reports this interaction (PMID 11889121)
15

Data Source:
HPRD (in vitro, in vivo)

		GUCY2C	GUCA2A
Gene Name		guanylate cyclase 2C	guanylate cyclase activator 2A (guanylin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding	Hormone Activity Guanylate Cyclase Activator Activity
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Proliferation	Positive Regulation Of Guanylate Cyclase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GUCA2A PDZD3 SRC	1 interactors: GUCY2C
Entrez ID		2984	2980
HPRD ID		07529	00767
Ensembl ID		ENSG00000070019	ENSG00000197273
Uniprot IDs		P25092	Q02747
PDB IDs			1GNA 1GNB 1O8R
Enriched GO Terms of Interacting Partners?		Regulation Of CGMP Biosynthetic Process Regulation Of CGMP Metabolic Process Regulation Of Cyclase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of CGMP Biosynthetic Process Cellular Response To Progesterone Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Regulation Of Podosome Assembly Regulation Of Caveolin-mediated Endocytosis Regulation Of Catalytic Activity Osteoclast Development Negative Regulation Of Protein Oligomerization CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Regulation Of Integrin Activation Regulation Of Early Endosome To Late Endosome Transport Transcytosis Signal Complex Assembly Stress Fiber Assembly Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Uterus Development Positive Regulation Of CGMP Biosynthetic Process Intracellular Estrogen Receptor Signaling Pathway Regulation Of Anoikis Response To Acidic PH Regulation Of Mitochondrial Depolarization Positive Regulation Of CGMP Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Lyase Activity Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Catalytic Activity Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Protein Oligomerization Activation Of Protein Kinase B Activity	Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Response To Toxic Substance Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process
Tagcloud ?		abrogation antigens autoimmunity cd4 cd8 creates cyclase durable elimination epitopes foreign formidable guanylyl immunotherapeutics incorporating inefficacy offered pools preservation presumably prevailing reconstituted reflects revealing tolerance trp2 unbiased underlies vaccines
Tagcloud (Difference) ?		abrogation antigens autoimmunity cd4 cd8 creates cyclase durable elimination epitopes foreign formidable guanylyl immunotherapeutics incorporating inefficacy offered pools preservation presumably prevailing reconstituted reflects revealing tolerance trp2 unbiased underlies vaccines
Tagcloud (Intersection) ?