GUCY2C

Description		guanylate cyclase 2C
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding Lyase Activity Phosphorus-oxygen Lyase Activity
	Biological Process	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Cyclic Nucleotide Biosynthetic Process Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Population Proliferation
Pathways		Digestion Intestinal infectious diseases
Drugs		Linaclotide
Diseases
GWAS
Interacting Genes		3 interacting genes: GUCA2A NHERF4 SRC
Entrez ID		2984
HPRD ID		07529
Ensembl ID		ENSG00000070019
Uniprot IDs		P25092
PDB IDs		8FX4 8GHO 8GHP
Enriched GO Terms of Interacting Partners?		Guanylate Cyclase Activator Activity Bone Resorption Angiotensin-activated Signaling Pathway Signaling Receptor Binding Negative Regulation Of Hippo Signaling Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Caveolin-mediated Endocytosis Connexin Binding Regulation Of Lamellipodium Morphogenesis Regulation Of Integrin Activation Positive Regulation Of Dephosphorylation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Maturation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Signal Complex Assembly Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Mitochondrial Depolarization Uterus Development Negative Regulation Of Focal Adhesion Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Neutrophil Activation Response To Platelet-derived Growth Factor Endolysosomal Toll-like Receptor Signaling Pathway Contractile Actin Filament Bundle Assembly Regulation Of Dephosphorylation Stress Fiber Assembly Progesterone Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phospholipase Binding Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Anoikis Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Glycolytic Process Neutrophil Activation Involved In Immune Response
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