BLNK and NCK1

Number of citations of the paper that reports this interaction (PubMedID 11487585)
0

Data Source:
HPRD (in vivo, two hybrid)

		BLNK	NCK1
Description		B cell linker	NCK adaptor protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Lipid Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Molecular Condensate Scaffold Activity Protein Tyrosine Kinase Binding	Protein Kinase Inhibitor Activity Signaling Receptor Binding Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Cadherin Binding Ephrin Receptor Binding Eukaryotic Initiation Factor EIF2 Binding Protein Sequestering Activity Molecular Condensate Scaffold Activity
	Biological Process	Inflammatory Response Humoral Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Activation B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuron Projection Development Cell Migration Lamellipodium Assembly Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Response To Endoplasmic Reticulum Stress Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Ephrin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Response To Other Organism Antiviral Innate Immune Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Regulation of signaling by CBL Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Downstream signal transduction Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Nephrin family interactions DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHOU GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS PKR-mediated signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Mean spheric corpuscular volume ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Blood urea nitrogen levels ( 31152163) Body mass index ( 25673413) Monocyte count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	97 interacting genes: ABI1 ABI2 ABL1 ADAM15 ADGRL2 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CHN2 CRK CSNK1G2 CYFIP2 DAG1 DCC DLGAP4 DNM1 DOK1 DOK2 DRD3 DRD4 DSCAM EFS EGFR EIF2AK2 EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB2 ERBB3 ERBB4 FASLG FCHO1 FGFR1 FLT1 FLT3 FNDC3B FRS2 GAB1 GAB2 GMPPA HOMEZ KDR KHDRBS1 KIT LCP2 MAP4K1 MAP4K4 MET MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NHSL2 NPHS1 NTRK2 NUTM2F OLIG1 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PIK3AP1 PIK3R3 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SH2D1A SHANK3 SOCS1 SOCS7 SORBS3 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1
Entrez ID		29760	4690
HPRD ID		05153	02740
Ensembl ID		ENSG00000095585	ENSG00000158092
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	A0A0S2Z4Y3 P16333
PDB IDs		6YLU	2CI8 2CI9 2CUB 2JS0 2JS2 2JW4 5QU1 5QU2 5QU3 5QU4 5QU5 5QU6 5QU7 5QU8 5QUA
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Leukocyte Activation Lymphocyte Activation B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell-cell Junction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling T Cell Activation Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Leukocyte Proliferation ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Receptor Tyrosine Kinase Binding Cell Population Proliferation Plasma Membrane Negative Regulation Of Immune System Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Protein Kinase Activity Intracellular Signal Transduction SH3 Domain Binding Intracellular Signaling Cassette Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Kinase Activity Kinase Activity Cell Migration Phosphorylation Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Regulation Of Intracellular Signal Transduction Cell Motility Focal Adhesion Cytosol Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Actin Filament Organization Regulation Of Cytoskeleton Organization Plasma Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Supramolecular Fiber Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Organization Regulation Of Anatomical Structure Morphogenesis Lamellipodium Peptidyl-tyrosine Phosphorylation Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Developmental Process
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