BLNK and LCP2

Number of citations of the paper that reports this interaction (PubMedID 9697839)
0

Data Source:
HPRD (in vitro, in vivo)

		BLNK	LCP2
Description		B cell linker	lymphocyte cytosolic protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Lipid Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Molecular Condensate Scaffold Activity Protein Tyrosine Kinase Binding	Protein Binding
	Biological Process	Inflammatory Response Humoral Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Activation B Cell Receptor Signaling Pathway	Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway
Pathways		Regulation of signaling by CBL Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Mean spheric corpuscular volume ( 32888494)	Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		29760	3937
HPRD ID		05153	03362
Ensembl ID		ENSG00000095585	ENSG00000043462
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	Q13094
PDB IDs		6YLU	1H3H 1YWO 2EAP 2ROR 6ZCJ
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Leukocyte Activation Lymphocyte Activation B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell-cell Junction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling T Cell Activation Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Leukocyte Proliferation ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Receptor Tyrosine Kinase Binding Cell Population Proliferation Plasma Membrane Negative Regulation Of Immune System Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Signal Transduction Cell Activation Regulation Of MAPK Cascade Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Activation Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Membrane Raft Ephrin Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Regulation Of Signaling
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