BLNK and CRKL

Number of citations of the paper that reports this interaction (PubMedID 11489945)
64

Data Source:
HPRD (in vivo)

		BLNK	CRKL
Description		B cell linker	CRK like proto-oncogene, adaptor protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Lipid Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Molecular Condensate Scaffold Activity Protein Tyrosine Kinase Binding	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Inflammatory Response Humoral Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Activation B Cell Receptor Signaling Pathway	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration
Pathways		Regulation of signaling by CBL Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Mean spheric corpuscular volume ( 32888494)	Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	78 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1
Entrez ID		29760	1399
HPRD ID		05153	03596
Ensembl ID		ENSG00000095585	ENSG00000099942
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	P46109
PDB IDs		6YLU	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Leukocyte Activation Lymphocyte Activation B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell-cell Junction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling T Cell Activation Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Leukocyte Proliferation ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Receptor Tyrosine Kinase Binding Cell Population Proliferation Plasma Membrane Negative Regulation Of Immune System Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation
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