BLNK and PLCG2

Number of citations of the paper that reports this interaction (PMID 11274146)
13

Data Source:
HPRD (in vivo)

		BLNK	PLCG2
Gene Name		B-cell linker	phospholipase C, gamma 2 (phosphatidylinositol-specific)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Plasma Membrane	Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Protein Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Follicular B Cell Differentiation Phosphatidylinositol Biosynthetic Process Blood Coagulation Phospholipid Catabolic Process Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Platelet Activation B Cell Differentiation Activation Of Store-operated Calcium Channel Activity Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Programmed Cell Death Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by Interleukins Regulation of signaling by CBL Cytokine Signaling in Immune system Interleukin-3, 5 and GM-CSF signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Signaling by the B Cell Receptor (BCR) DAP12 interactions FCERI mediated MAPK activation Inositol phosphate metabolism DAP12 signaling Toll-Like Receptors Cascades Synthesis of IP3 and IP4 in the cytosol Toll Like Receptor 4 (TLR4) Cascade Role of phospholipids in phagocytosis GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Platelet activation, signaling and aggregation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B
Entrez ID		29760	5336
HPRD ID		05153	02570
Ensembl ID		ENSG00000095585	ENSG00000197943
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	P16885
PDB IDs			2K2J 2W2W 2W2X
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Activation Immune Response Immune System Process Signal Transduction Regulation Of Lymphocyte Activation Signaling Cell Communication Regulation Of T Cell Activation Regulation Of Cell Activation Leukocyte Activation Defense Response B Cell Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Response To Stimulus Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Platelet Activation Positive Regulation Of Cell Adhesion Chemotaxis Wound Healing Positive Regulation Of T Cell Activation Locomotion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Response To Stress	Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response Protein Autophosphorylation Immune System Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Defense Response Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Cell Communication B Cell Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Peptidyl-amino Acid Modification Cell Activation Positive Regulation Of Signal Transduction Response To Stimulus Response To Stress Leukocyte Activation Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Activation Cell Migration Locomotion Phosphorylation Cell Motility Mast Cell Activation Phosphatidylinositol-mediated Signaling Wound Healing Leukocyte Migration Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway
Tagcloud ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl
Tagcloud (Difference) ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl
Tagcloud (Intersection) ?