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BLNK and ITK
Number of citations of the paper that reports this interaction (PubMedID
10556826
)
0
Data Source:
HPRD
(in vitro)
BLNK
ITK
Description
B cell linker
IL2 inducible T cell kinase
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Lipid Binding
Enzyme Binding
Protein Kinase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Phospholipase Binding
Molecular Condensate Scaffold Activity
Protein Tyrosine Kinase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Biological Process
Inflammatory Response
Humoral Immune Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
B Cell Differentiation
Intracellular Signal Transduction
B Cell Activation
B Cell Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Immune System Process
Cellular Defense Response
Signal Transduction
Intracellular Signal Transduction
T Cell Activation
Gamma-delta T Cell Activation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Pathways
Regulation of signaling by CBL
Potential therapeutics for SARS
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Drugs
Staurosporine
Pazopanib
Fostamatinib
Zanubrutinib
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Mean spheric corpuscular volume (
32888494
)
Asthma (
31959851
34103634
)
Daytime sleep phenotypes (
27126917
)
Eosinophil count (
32888494
)
Heel bone mineral density (
30598549
)
Personality traits in bipolar disorder (
21368711
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Interacting Genes
25 interacting genes:
AR
BTK
CBL
CBLB
CD72
CD79A
CMTM3
CRKL
EGFR
ERBB2
ERBB3
GAB1
GRAP2
GRB2
ITK
KIT
LCP2
MAP4K1
NCK1
PLCG1
PLCG2
PTPN6
SH3KBP1
SYK
VAV1
34 interacting genes:
BLNK
BMX
BTK
CBL
CD28
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FYN
GAB1
GRB2
HNRNPK
IKBKG
KHDRBS1
KPNA2
LAT
LCK
LCP2
MET
PLCG1
PLCG2
PPIA
SH2D2A
SMAD4
SMURF1
SOCS1
SPRR2A
SRC
TGFBR1
WAS
Entrez ID
29760
3702
HPRD ID
05153
01746
Ensembl ID
ENSG00000095585
ENSG00000113263
Uniprot IDs
Q2MD54
Q2MD59
Q8WV28
Q08881
PDB IDs
6YLU
1SM2
1SNU
1SNX
2E6I
2LMJ
2YUQ
3MIY
3MJ1
3MJ2
3QGW
3QGY
3T9T
3V5J
3V5L
3V8T
3V8W
4HCT
4HCU
4HCV
4KIO
4L7S
4M0Y
4M0Z
4M12
4M13
4M14
4M15
4MF0
4MF1
4PP9
4PPA
4PPB
4PPC
4PQN
4QD6
4RFM
Enriched GO Terms of Interacting Partners
?
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Immune Response-regulating Signaling Pathway
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune Response
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Leukocyte Activation
Lymphocyte Activation
B Cell Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Activation
Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cell-cell Junction
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Fc Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
T Cell Activation
Immune System Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Protein Tyrosine Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Leukocyte Proliferation
ERBB Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
Receptor Tyrosine Kinase Binding
Cell Population Proliferation
Plasma Membrane
Negative Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
T Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cell Activation
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Signal Transduction
Phospholipase Binding
ERBB Signaling Pathway
Regulation Of Apoptotic Process
Immune System Process
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Protein Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Immune Response
Intracellular Signaling Cassette
Leukocyte Activation
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Kinase Activity
Regulation Of Immune Response
Regulation Of MAPK Cascade
Membrane Raft
Positive Regulation Of Immune System Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Programmed Cell Death
ERBB2 Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Binding
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Tagcloud (Intersection)
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