BLNK and MAP4K1

Number of citations of the paper that reports this interaction (PMID 11514608)
15

Data Source:
HPRD (in vitro)

		BLNK	MAP4K1
Gene Name		B-cell linker	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Plasma Membrane	Cytoplasm Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Activation Of MAPKKK Activity Protein Phosphorylation Response To Stress Activation Of JUN Kinase Activity Cell Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by Interleukins Regulation of signaling by CBL Cytokine Signaling in Immune system Interleukin-3, 5 and GM-CSF signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	20 interactors: ABL1 BLNK CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		29760	11184
HPRD ID		05153	03583
Ensembl ID		ENSG00000095585	ENSG00000104814
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	Q92918
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Activation Immune Response Immune System Process Signal Transduction Regulation Of Lymphocyte Activation Signaling Cell Communication Regulation Of T Cell Activation Regulation Of Cell Activation Leukocyte Activation Defense Response B Cell Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Response To Stimulus Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Platelet Activation Positive Regulation Of Cell Adhesion Chemotaxis Wound Healing Positive Regulation Of T Cell Activation Locomotion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Response To Stress	Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Immune System Process Regulation Of Protein Kinase Activity Fc-epsilon Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of MAPK Cascade Regulation Of Immune Response Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Activation Immune Response Positive Regulation Of Protein Phosphorylation Defense Response Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Kinase Activity Platelet Activation Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process MAPK Cascade Cell Surface Receptor Signaling Pathway
Tagcloud ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste
Tagcloud (Difference) ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste
Tagcloud (Intersection) ?