IGSF21 and NREP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IGSF21	NREP
Gene Name		immunoglobin superfamily, member 21	neuronal regeneration related protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Nucleus Cytoplasm
	Molecular Function		Protein Binding
	Biological Process		Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2	3 interactors: EEF1A1 IGSF21 KMT2B
Entrez ID		84966	9315
HPRD ID		11309	09545
Ensembl ID		ENSG00000117154	ENSG00000134986
Uniprot IDs		Q96ID5	Q16612
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth	Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Trimethylation Positive Regulation Of Gene Expression, Epigenetic Ovulation Regulation Of Histone H3-K4 Methylation Cellular Response To Epidermal Growth Factor Stimulus Peptidyl-lysine Trimethylation Response To Epidermal Growth Factor Histone H3-K4 Methylation
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