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IGSF21 and DGKD
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
IGSF21
DGKD
Gene Name
immunoglobin superfamily, member 21
diacylglycerol kinase, delta 130kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Cytoplasm
Plasma Membrane
Cytoplasmic Membrane-bounded Vesicle
Molecular Function
NAD+ Kinase Activity
Diacylglycerol Kinase Activity
Protein Binding
ATP Binding
Diacylglycerol Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Endocytosis
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway
Multicellular Organismal Development
Blood Coagulation
Response To Organic Substance
Protein Transport
Cell Growth
Phosphorylation
Second-messenger-mediated Signaling
Platelet Activation
Diacylglycerol Metabolic Process
Protein Homooligomerization
Pathways
G alpha (q) signalling events
G alpha (q) signalling events
Signaling by GPCR
GPCR downstream signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Platelet activation, signaling and aggregation
Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS
Diabetic retinopathy (
21441570
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Bilirubin levels (
20639394
)
Calcium levels (
20705733
)
Crohn's disease (
22412388
)
Protein-Protein Interactions
32 interactors:
ALDH2
ANXA3
ATF3
BCR
BTBD2
CRCT1
DGKD
EPB41L3
ERH
ETHE1
GADD45A
GIPC2
GSK3B
GSTM4
HSPB1
KRAS
MAD2L1BP
NACA
NREP
PAEP
PAFAH1B3
PCDHA4
PRMT1
PSMD11
RPP14
S100A8
SEPHS1
SERPINB9
SULT1E1
TMSB4X
TRBV2
UBE2V2
7 interactors:
DGKH
HAX1
IGSF21
MYH2
PRKCA
SREK1
TNFRSF14
Entrez ID
84966
8527
HPRD ID
11309
03492
Ensembl ID
ENSG00000117154
ENSG00000077044
Uniprot IDs
Q96ID5
Q16760
PDB IDs
1R79
3BQ7
Enriched GO Terms of Interacting Partners
?
Response To Wounding
Regulation Of Apoptotic Process
Regulation Of Cell Death
Wound Healing
Positive Regulation Of Protein Metabolic Process
Response To Stress
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Negative Regulation Of Catalytic Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Response To Stimulus
Developmental Process
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Response To Xenobiotic Stimulus
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Apoptotic Process
Epidermal Growth Factor Receptor Signaling Pathway
Nervous System Development
ERBB Signaling Pathway
Regulation Of Proteolysis
Programmed Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Death
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Death
Cellular Response To Stimulus
Blood Coagulation
Platelet Activation
Hemostasis
Regulation Of Protein Kinase Activity
Response To Biotic Stimulus
Multicellular Organismal Development
Positive Regulation Of Catalytic Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Rac GTPase Activity
Positive Regulation Of Endothelial Cell Migration
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Growth
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Immune System Process
Positive Regulation Of Myeloid Leukocyte Differentiation
Regulation Of Cellular Amino Acid Metabolic Process
Regulation Of Immune System Process
Positive Regulation Of Myeloid Cell Differentiation
Regulation Of Cellular Ketone Metabolic Process
Positive Regulation Of Dense Core Granule Biogenesis
Wound Healing
Regulation Of Myeloid Leukocyte Differentiation
Regulation Of Protein Transport
Regulation Of Establishment Of Protein Localization
Response To Wounding
Histone H3-T6 Phosphorylation
Response To Cytokine
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Protein Localization
Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Phosphorylation
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Platelet Activation
Positive Regulation Of Protein Modification Process
Regulation Of Cellular Localization
Regulation Of Protein Phosphorylation
Peptidyl-serine Autophosphorylation
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Alpha-beta T Cell Proliferation
Plasma Membrane Repair
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Granulocyte Differentiation
Desmosome Assembly
Negative Regulation Of Glial Cell Apoptotic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Mitochondrion Degradation
Negative Regulation Of Glucose Import
Positive Regulation Of Cell Migration
Immune Response
Positive Regulation Of Cell Motility
Regulation Of Phosphorylation
Positive Regulation Of Macrophage Differentiation
Regulation Of Cytokine Secretion Involved In Immune Response
Positive Regulation Of Cellular Component Movement
Defense Response
Desmosome Organization
Positive Regulation Of Locomotion
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway
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Tagcloud (Intersection)
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