IGSF21 and EPB41L3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		IGSF21	EPB41L3
Gene Name		immunoglobin superfamily, member 21	erythrocyte membrane protein band 4.1-like 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Extrinsic Component Of Membrane Axolemma Paranode Region Of Axon Juxtaparanode Region Of Axon
	Molecular Function		Actin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process		Protein Localization To Paranode Region Of Axon Apoptotic Process Cytoskeletal Anchoring At Plasma Membrane Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2	17 interactors: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 IGSF21 MBIP PAXIP1 PSEN1 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		84966	23136
HPRD ID		11309	05622
Ensembl ID		ENSG00000117154	ENSG00000082397
Uniprot IDs		Q96ID5	A8K968 B7Z4I5 F5GX05 Q9Y2J2
PDB IDs			2HE7 3BIN
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Nervous System Development Regulation Of Protein Localization Cellular Localization Membrane Organization System Development Cellular Protein Localization Protein Localization Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell Apoptotic Process Establishment Of Protein Localization Programmed Cell Death Intracellular Transport Apoptotic Signaling Pathway Cell Death Death Multicellular Organismal Development Regulation Of Synaptic Plasticity Anatomical Structure Development Brain Development Head Development Positive Regulation Of Signal Transduction Intracellular Signal Transduction Cellular Component Assembly Developmental Process Regulation Of Apoptotic Process Central Nervous System Development Regulation Of Cell Death Generation Of Neurons Regulation Of Synaptic Transmission
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