IGSF21 and ANXA3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IGSF21	ANXA3
Gene Name		immunoglobin superfamily, member 21	annexin A3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Cytoplasm Plasma Membrane Membrane Phagocytic Vesicle Membrane Specific Granule Extracellular Vesicular Exosome
	Molecular Function		Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Calcium-dependent Protein Binding
	Biological Process		Phagocytosis Positive Regulation Of Endothelial Cell Migration Defense Response To Bacterium Negative Regulation Of Catalytic Activity Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)	Non-albumin protein levels ( 22558069) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2	6 interactors: EMG1 IGSF21 REG3A TP53 UBR1 UNC119
Entrez ID		84966	306
HPRD ID		11309	00111
Ensembl ID		ENSG00000117154	ENSG00000138772
Uniprot IDs		Q96ID5	P12429
PDB IDs			1AII 1AXN
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth	Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Keratinocyte Differentiation Regulation Of Caveolin-mediated Endocytosis Mitochondrial DNA Repair Response To Leucine Positive Regulation Of Keratinocyte Proliferation Mitotic Cytokinetic Process Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Response To Light Stimulus Negative Regulation Of Epidermal Cell Differentiation ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation Regulation Of Cellular Amino Acid Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Thymocyte Apoptotic Process RRNA Methylation Response To Radiation Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior RRNA Modification Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Cell Separation After Cytokinesis Rhythmic Behavior Lipoprotein Transport Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Tagcloud ?			1e 3e 7e accessed adam28 adenocarcinomas cabig cadm1 ccne1 cd24 cdk1 cdkn2a com datasets demonstration ercc1 geo kmplot logrank online opn plot plotted rad51 repositories silico tcga uni www
Tagcloud (Difference) ?			1e 3e 7e accessed adam28 adenocarcinomas cabig cadm1 ccne1 cd24 cdk1 cdkn2a com datasets demonstration ercc1 geo kmplot logrank online opn plot plotted rad51 repositories silico tcga uni www
Tagcloud (Intersection) ?