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IGSF21 and S100A8
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
IGSF21
S100A8
Gene Name
immunoglobin superfamily, member 21
S100 calcium binding protein A8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Region
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
Calcium Ion Binding
Protein Binding
Microtubule Binding
Zinc Ion Binding
Toll-like Receptor 4 Binding
Arachidonic Acid Binding
RAGE Receptor Binding
Biological Process
Cytokine Production
Leukocyte Migration Involved In Inflammatory Response
Acute Inflammatory Response
Chronic Inflammatory Response
Positive Regulation Of Peptide Secretion
Autophagy
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Response To Zinc Ion
Positive Regulation Of Cell Growth
Neutrophil Chemotaxis
Sequestering Of Zinc Ion
Response To Lipopolysaccharide
Chemokine Production
Wound Healing
Defense Response To Bacterium
Innate Immune Response
Response To Ethanol
Positive Regulation Of Inflammatory Response
Defense Response To Fungus
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cytoskeleton Organization
Neutrophil Aggregation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Diabetic retinopathy (
21441570
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Protein-Protein Interactions
32 interactors:
ALDH2
ANXA3
ATF3
BCR
BTBD2
CRCT1
DGKD
EPB41L3
ERH
ETHE1
GADD45A
GIPC2
GSK3B
GSTM4
HSPB1
KRAS
MAD2L1BP
NACA
NREP
PAEP
PAFAH1B3
PCDHA4
PRMT1
PSMD11
RPP14
S100A8
SEPHS1
SERPINB9
SULT1E1
TMSB4X
TRBV2
UBE2V2
18 interactors:
APP
C14orf1
CDKN1A
CEACAM3
CHGB
GDF9
IGSF21
KLC2
LRIF1
NCF2
PDCD11
PPIA
PRMT1
RAB17
S100A9
TP53
TUBA4A
UNC119
Entrez ID
84966
6279
HPRD ID
11309
00471
Ensembl ID
ENSG00000117154
ENSG00000143546
Uniprot IDs
Q96ID5
P05109
PDB IDs
1MR8
1XK4
4GGF
Enriched GO Terms of Interacting Partners
?
Response To Wounding
Regulation Of Apoptotic Process
Regulation Of Cell Death
Wound Healing
Positive Regulation Of Protein Metabolic Process
Response To Stress
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Negative Regulation Of Catalytic Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Response To Stimulus
Developmental Process
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Response To Xenobiotic Stimulus
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Apoptotic Process
Epidermal Growth Factor Receptor Signaling Pathway
Nervous System Development
ERBB Signaling Pathway
Regulation Of Proteolysis
Programmed Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Death
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Death
Cellular Response To Stimulus
Blood Coagulation
Platelet Activation
Hemostasis
Regulation Of Protein Kinase Activity
Response To Biotic Stimulus
Multicellular Organismal Development
Positive Regulation Of Catalytic Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Rac GTPase Activity
Positive Regulation Of Endothelial Cell Migration
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Growth
Blood Coagulation
Hemostasis
Platelet Degranulation
Immune System Process
Stress-induced Premature Senescence
Regulation Of Body Fluid Levels
Wound Healing
Regulation Of Growth
Mitotic Cell Cycle Arrest
Positive Regulation Of Cellular Protein Metabolic Process
Response To Light Stimulus
Response To Wounding
Regulation Of Cell Growth
Positive Regulation Of Protein Metabolic Process
Immune Response
Negative Regulation Of Cell Growth
Response To Radiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To X-ray
Cellular Senescence
Response To Hyperoxia
Platelet Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Mitotic Cell Cycle Phase Transition
Ras Protein Signal Transduction
Positive Regulation Of Cell Cycle Process
Regulation Of Protein Phosphorylation
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of Cell Cycle Phase Transition
Response To Stimulus
Response To Abiotic Stimulus
Positive Regulation Of Programmed Cell Death
Axon Cargo Transport
Negative Regulation Of Growth
Response To Stress
Positive Regulation Of Cell Death
Response To External Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Neuron Apoptotic Process
Cellular Response To Ionizing Radiation
Signal Transduction Involved In DNA Damage Checkpoint
Positive Regulation Of Neuron Apoptotic Process
Signal Transduction Involved In Cell Cycle Checkpoint
Cellular Response To UV
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cell Cycle
Negative Regulation Of Clathrin-mediated Endocytosis
Uncoating Of Virus
Mitotic Cell Cycle Process
Tagcloud
?
a9
auscan
australian
canadian
erythrocyte
esr
exploratory
grades
hand
hip
inverse
joint
kellgren
knee
lawrence
mcmaster
narrowing
oa
ontario
osteoarthritis
osteophytes
sedimentation
space
stiffness
structural
sum
synovial
universities
womac
Tagcloud (Difference)
?
a9
auscan
australian
canadian
erythrocyte
esr
exploratory
grades
hand
hip
inverse
joint
kellgren
knee
lawrence
mcmaster
narrowing
oa
ontario
osteoarthritis
osteophytes
sedimentation
space
stiffness
structural
sum
synovial
universities
womac
Tagcloud (Intersection)
?