CHN2 and BAG6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHN2	BAG6
Gene Name		chimerin 2	BCL2-associated athanogene 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle BAT3 Complex
	Molecular Function	SH3/SH2 Adaptor Activity GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Hsp70 Protein Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding Ribosome Binding Proteasome Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Kidney Development Immune System Process Ubiquitin-dependent Protein Catabolic Process Transport Synaptonemal Complex Assembly Spermatogenesis Brain Development Embryo Development Chromatin Modification Internal Peptidyl-lysine Acetylation Cell Differentiation Lung Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Protein Stabilization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Schizophrenia ( 23894747)
Protein-Protein Interactions		6 interactors: AKT1 BAG6 ERBB3 RAC1 RACGAP1 TGFBR1	102 interactors: ACVR1B AMFR ANXA7 ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CHN2 CLU CSNK2B CSTF2 CTCFL CTSB CTSE CTSL CXCL8 DNAJB11 DPT EDN1 EFEMP1 EFEMP2 EP300 FAM173A FAM46A FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GSK3B HSPA13 HSPA8 ICK IGF2 IGFBP5 IKBKAP IMMT IQCG KLHL12 LBP LPPR3 MAPK6 MAVS MEST MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 POLR2J PPAP2C PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TFCP2 TK1 TOMM20 TP63 TTR UBL4A UBL7 UBQLN4 VAMP2 XRN1 ZFYVE9
Entrez ID		1124	7917
HPRD ID		04173	00808
Ensembl ID		ENSG00000106069	ENSG00000204463
Uniprot IDs		A4D1A2 B3VCF5 B3VCG4 B7Z1V0 P52757	P46379
PDB IDs		1XA6	1WX9 4DWF 4EEW
Enriched GO Terms of Interacting Partners?		Wound Healing Response To Wounding Intracellular Signal Transduction Immune System Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Nervous System Development Cell Death Death Embryo Development Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Apoptotic Process Response To Growth Factor Positive Regulation Of Catalytic Activity Regulation Of Cell Death Gamete Generation Cell Differentiation Neurogenesis Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Kinase Activity Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process System Development Negative Regulation Of Programmed Cell Death Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Reproduction Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Response To Organic Substance Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Immune System Process Regulation Of Protein Phosphorylation Cellular Response To Stimulus Defense Response Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Cell Cycle Response To External Stimulus Signal Transduction Developmental Process Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cell Development System Development Regulation Of Phosphorylation Regulation Of Signal Transduction Response To Hormone Immune System Process Response To Lipid Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Protein Metabolic Process Regulation Of Cellular Process Cellular Process Regulation Of Catalytic Activity Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Regulation Of Cell Motility Apoptotic Signaling Pathway Multicellular Organismal Development Positive Regulation Of Signal Transduction
Tagcloud ?		ala antibody bound cbz cysteine degraded dense endocytosis enzymes exchange exposing fibroblasts former lysosomal lysosomes mannose newly normally phe polyclonal polypeptides precursors proteinases recovered segregation smaller spared tagged transported	biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides sgta solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Difference) ?		ala antibody bound cbz cysteine degraded dense endocytosis enzymes exchange exposing fibroblasts former lysosomal lysosomes mannose newly normally phe polyclonal polypeptides precursors proteinases recovered segregation smaller spared tagged transported	biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides sgta solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Intersection) ?