CHN2 and SHF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHN2	SHF
Description		chimerin 2	Src homology 2 domain containing F
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Phosphotyrosine Residue Binding
	Biological Process	Acrosome Assembly Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Apoptotic Process Signal Transduction
Pathways		RAC1 GTPase cycle
Drugs
Diseases
GWAS		Circulating leptin levels in high cardiovascular risk ( 31766143) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Loneliness (linear analysis) ( 27629369) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Psychosis (atypical) ( 24132900) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 28552196)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Initial alcohol sensitivity ( 30276832)
Interacting Genes		14 interacting genes: ANKK1 BAG6 ERBB3 NCK1 NCK2 RAC1 RACGAP1 RANBP3 RB1 SENP8 SHF SMARCD1 TGFBR1 TP53RK	2 interacting genes: CHN2 PDGFRA
Entrez ID		1124	90525
HPRD ID		04173	14272
Ensembl ID		ENSG00000106069	ENSG00000138606
Uniprot IDs		A0A2X0TVW3 A0A994J7L4 B3VCF4 B3VCF5 B3VCF6 B3VCF9 B7Z1V0 B7Z1W9 B7Z215 P52757	A0A8I5QJ71 B3KTY1 B4DWP8 B4E1A9 F8W6V4 H0YLD8 H0YLM1 H0YLW6 Q7M4L6
PDB IDs		1XA6
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Lamellipodium Organization Positive Regulation Of Translation In Response To Stress Positive Regulation Of Cytoskeleton Organization Signal Complex Assembly Regulation Of Multicellular Organismal Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Actin Filament Organization Regulation Of PERK-mediated Unfolded Protein Response Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Immune System Process Regulation Of Actin Filament Polymerization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cell Morphogenesis Involved In Neuron Differentiation Cell Activation Regulation Of Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Actin Filament Length Positive Regulation Of Extracellular Matrix Organization Regulation Of Supramolecular Fiber Organization Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization SWI/SNF Complex Positive Regulation Of Gene Expression Signaling Receptor Complex Adaptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Adhesion	Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Alpha-receptor Activity Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Receptor-ligand Complex Vascular Endothelial Growth Factor Binding Glomerular Capillary Formation Locomotion Vascular Endothelial Growth Factor Receptor Activity Chemotaxis T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Luteinization Platelet-derived Growth Factor Binding Leydig Cell Differentiation Regulation Of Mesenchymal Stem Cell Differentiation Embryonic Digestive Tract Morphogenesis Positive Regulation Of Locomotion Male Genitalia Development Positive Regulation Of Cell Migration Platelet-derived Growth Factor Receptor Binding Positive Regulation Of Cell Motility White Fat Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Retina Vasculature Development In Camera-type Eye Negative Regulation Of Platelet Activation Cardiac Myofibril Assembly Smooth Muscle Cell Migration Ventricular System Development Semaphorin Receptor Binding Adrenal Gland Development Cell Activation Reproductive System Development Cell Surface Chemorepellent Activity Acrosome Assembly Organelle Assembly Embryonic Cranial Skeleton Morphogenesis Myofibril Assembly Female Gonad Development Face Morphogenesis Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Axon Extension Muscle Cell Migration Estrogen Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Platelet-derived Growth Factor Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Genitalia Development Ovulation Cycle Process
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