CHN2 and ERBB3

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		CHN2	ERBB3
Gene Name		chimerin 2	erb-b2 receptor tyrosine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Receptor Complex
	Molecular Function	SH3/SH2 Adaptor Activity GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Endocardial Cushion Development Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cranial Nerve Development Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Tyrosine Kinase Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661) Type 1 diabetes ( 19430480 18198356 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22951725)
Protein-Protein Interactions		6 interactors: AKT1 BAG6 ERBB3 RAC1 RACGAP1 TGFBR1	66 interactors: ABL1 ABL2 AGTR2 BCAR3 CD82 CDK5 CHN2 CRK CRKL DAB1 DAPP1 EGF EGFR EGR1 ERBB2 ERBB4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ITK JAK2 JAK3 MUC1 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTGES3 PTK2 PTK2B PTK6 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SYK TNS2 TNS3 TNS4 TXK VAV1 VAV2 VAV3 ZAP70 ZNF207
Entrez ID		1124	2065
HPRD ID		04173	01820
Ensembl ID		ENSG00000106069	ENSG00000065361
Uniprot IDs		A4D1A2 B3VCF5 B3VCG4 B7Z1V0 P52757	P21860
PDB IDs		1XA6	1M6B 2L9U 3KEX 3LMG 3P11 4LEO
Enriched GO Terms of Interacting Partners?		Wound Healing Response To Wounding Intracellular Signal Transduction Immune System Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Nervous System Development Cell Death Death Embryo Development Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Apoptotic Process Response To Growth Factor Positive Regulation Of Catalytic Activity Regulation Of Cell Death Gamete Generation Cell Differentiation Neurogenesis Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Kinase Activity Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process System Development Negative Regulation Of Programmed Cell Death Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Reproduction Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Signaling Regulation Of Signaling Cell Migration Signal Transduction Immune Response Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Cell Motility Locomotion Positive Regulation Of Signal Transduction Regulation Of Immune System Process Intracellular Signal Transduction Defense Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Activation Response To Growth Factor Response To Stress Positive Regulation Of Catalytic Activity Response To Stimulus Wound Healing Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Blood Coagulation Hemostasis
Tagcloud ?		ala antibody bound cbz cysteine degraded dense endocytosis enzymes exchange exposing fibroblasts former lysosomal lysosomes mannose newly normally phe polyclonal polypeptides precursors proteinases recovered segregation smaller spared tagged transported	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Difference) ?		ala antibody bound cbz cysteine degraded dense endocytosis enzymes exchange exposing fibroblasts former lysosomal lysosomes mannose newly normally phe polyclonal polypeptides precursors proteinases recovered segregation smaller spared tagged transported	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Intersection) ?