CHN2 and SENP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHN2	SENP8
Description		chimerin 2	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Cytosol Membrane Synapse	Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity
	Biological Process	Acrosome Assembly Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Protein Deneddylation Proteolysis Protein Deubiquitination Post-translational Protein Modification
Pathways		RAC1 GTPase cycle	UCH proteinases Neddylation
Drugs
Diseases
GWAS		Circulating leptin levels in high cardiovascular risk ( 31766143) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Loneliness (linear analysis) ( 27629369) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Psychosis (atypical) ( 24132900) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 28552196)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		14 interacting genes: ANKK1 BAG6 ERBB3 NCK1 NCK2 RAC1 RACGAP1 RANBP3 RB1 SENP8 SHF SMARCD1 TGFBR1 TP53RK	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		1124	123228
HPRD ID		04173	09784
Ensembl ID		ENSG00000106069	ENSG00000166192
Uniprot IDs		A0A2X0TVW3 A0A994J7L4 B3VCF4 B3VCF5 B3VCF6 B3VCF9 B7Z1V0 B7Z1W9 B7Z215 P52757	A8K8D3 Q96LD8
PDB IDs		1XA6	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Lamellipodium Organization Positive Regulation Of Translation In Response To Stress Positive Regulation Of Cytoskeleton Organization Signal Complex Assembly Regulation Of Multicellular Organismal Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Actin Filament Organization Regulation Of PERK-mediated Unfolded Protein Response Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Immune System Process Regulation Of Actin Filament Polymerization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cell Morphogenesis Involved In Neuron Differentiation Cell Activation Regulation Of Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Actin Filament Length Positive Regulation Of Extracellular Matrix Organization Regulation Of Supramolecular Fiber Organization Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization SWI/SNF Complex Positive Regulation Of Gene Expression Signaling Receptor Complex Adaptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Adhesion	Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Modification By Small Protein Conjugation Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Removal Cullin-RING Ubiquitin Ligase Complex Proteolysis Protein Metabolic Process Nucleoplasm Intrinsic Apoptotic Signaling Pathway Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Cysteine-type Deubiquitinase Activity Transforming Growth Factor Beta Receptor Binding Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Regulation Of Protein Neddylation Cytosol Apoptotic Signaling Pathway Cysteine-type Peptidase Activity Proteolysis Involved In Protein Catabolic Process Deubiquitinase Activity Mitotic Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Phase Transition COP9 Signalosome Proteasomal Protein Catabolic Process Regulation Of Postsynapse Assembly Signal Transduction Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly SMAD Binding Engulfment Of Target By Autophagosome Nucleus SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity SCF Ubiquitin Ligase Complex Macromolecule Catabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Catabolic Process
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