ZC3H7A and COL7A1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ZC3H7A	COL7A1
Gene Name		zinc finger CCCH-type containing 7A	collagen, type VII, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Poly(A) RNA Binding Metal Ion Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process		Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways			Collagen formation Laminin interactions Collagen degradation Anchoring fibril formation Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		QT interval ( 19305408)
Protein-Protein Interactions		3 interactors: COL7A1 PAK1 STK3	14 interactors: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MMP2 SHKBP1 THBS1 ZC3H7A
Entrez ID		29066	1294
HPRD ID		11694	00358
Ensembl ID		ENSG00000122299	ENSG00000114270
Uniprot IDs		Q8IWR0	Q02388 Q59F16
PDB IDs		2D9M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Epithelium Development Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Protein Autophosphorylation Tissue Development Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Cellular Protein Metabolic Process Epithelial Tube Morphogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-T11 Phosphorylation Regulation Of Protein Metabolic Process Tube Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Primitive Hemopoiesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Regulation Of Cell Motility Embryonic Morphogenesis Tissue Morphogenesis Regulation Of Axon Regeneration Endocardium Development Negative Regulation Of Cell Proliferation Regulation Of Locomotion Hepatocyte Apoptotic Process Regulation Of Cellular Component Movement Tube Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Kinase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hyperosmotic Response Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cell Differentiation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Hippo Signaling Positive Regulation Of Phosphorylation Embryonic Hemopoiesis	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Blood Vessel Development Vasculature Development Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Blood Vessel Morphogenesis Locomotion Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Endodermal Cell Differentiation Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Retinal Blood Vessel Morphogenesis Cell Junction Assembly Endoderm Formation Cellular Response To Amino Acid Stimulus Developmental Process Collagen Catabolic Process Organ Morphogenesis Intramembranous Ossification Collagen Metabolic Process Cell Morphogenesis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Skeletal System Morphogenesis Bone Trabecula Formation Endoderm Development Multicellular Organismal Metabolic Process Multicellular Organismal Development Cell Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Hemidesmosome Assembly Response To Amino Acid Bone Trabecula Morphogenesis Axon Guidance Formation Of Primary Germ Layer System Development Cell Projection Morphogenesis Cell Part Morphogenesis Retina Vasculature Development In Camera-type Eye Morphogenesis Of A Polarized Epithelium Cellular Response To Acid Chemical Branching Involved In Salivary Gland Morphogenesis Gastrulation Platelet Activation
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