ZC3H7A and LARP4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		ZC3H7A	LARP4
Description		zinc finger CCCH-type containing 7A	La ribonucleoprotein 4
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GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytosolic Small Ribosomal Subunit
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding MiRNA Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding
	Biological Process	Post-transcriptional Regulation Of Gene Expression MiRNA Processing	Translation Cytoskeleton Organization Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Morphogenesis Positive Regulation Of Translation
Pathways
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) QT interval ( 19305408) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic widespread musculoskeletal pain ( 33331911) Pulse pressure ( 30578418)
Interacting Genes		10 interacting genes: COL7A1 LARP4 MIR16-2 MIR29A MIR7-1 MIR92A2 MORF4L1 PAK1 STK3 WDR83	25 interacting genes: APP BCAS2 BHLHE40 CRX EXOSC7 FNDC3B KAT5 LENG1 LRRK2 LSM5 PAX5 PAX6 PCM1 PFDN5 POU6F2 PRC1 PRPF39 PRPF6 TGM5 TXNL4A WBP4 YPEL3 YTHDF3 ZC3H7A ZNF830
Entrez ID		29066	113251
HPRD ID		11694	17289
Ensembl ID		ENSG00000122299	ENSG00000161813
Uniprot IDs		Q8IWR0	Q6P4E2 Q71RC2 Q8TBL5 Q96J85
PDB IDs		2D9M	2CQK 3PKN 6I9B
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Organ Growth	Spliceosomal Complex RNA Splicing U2-type Precatalytic Spliceosome MRNA Processing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Cellular Response To Manganese Ion Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Manganese Ion Nucleus Retina Development In Camera-type Eye Golgi-associated Vesicle Regulation Of Amyloid Fibril Formation Cellular Response To Catecholamine Stimulus Cellular Component Assembly Response To Catecholamine U5 SnRNP Microtubule Cytoskeleton Organization Nucleoplasm Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Microtubule-based Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development RNA Binding Establishment Of Mitotic Spindle Orientation RNA Polymerase III Assembly RNA Polymerase I Assembly Histone H2AK5 Acetyltransferase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly
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