ZC3H7A and STK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZC3H7A	STK3
Gene Name		zinc finger CCCH-type containing 7A	serine/threonine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol
	Molecular Function	Poly(A) RNA Binding Metal Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process		Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		QT interval ( 19305408)
Protein-Protein Interactions		3 interactors: COL7A1 PAK1 STK3	33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		29066	6788
HPRD ID		11694	05433
Ensembl ID		ENSG00000122299	ENSG00000104375
Uniprot IDs		Q8IWR0	B3KYA7 Q13188
PDB IDs		2D9M	4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Epithelium Development Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Protein Autophosphorylation Tissue Development Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Cellular Protein Metabolic Process Epithelial Tube Morphogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-T11 Phosphorylation Regulation Of Protein Metabolic Process Tube Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Primitive Hemopoiesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Regulation Of Cell Motility Embryonic Morphogenesis Tissue Morphogenesis Regulation Of Axon Regeneration Endocardium Development Negative Regulation Of Cell Proliferation Regulation Of Locomotion Hepatocyte Apoptotic Process Regulation Of Cellular Component Movement Tube Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Kinase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hyperosmotic Response Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cell Differentiation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Hippo Signaling Positive Regulation Of Phosphorylation Embryonic Hemopoiesis	Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?			contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?			contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?