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GRIN2B and CAPN1
Number of citations of the paper that reports this interaction (PubMedID
10846184
)
0
Data Source:
HPRD
(in vitro, in vivo)
GRIN2B
CAPN1
Description
glutamate ionotropic receptor NMDA type subunit 2B
calpain 1
Image
GO Annotations
Cellular Component
Cytoplasm
Lysosome
Endosome
Late Endosome
Endoplasmic Reticulum Membrane
Cytoskeleton
Plasma Membrane
Cell Surface
Postsynaptic Density
Membrane
NMDA Selective Glutamate Receptor Complex
Dendrite
Cell Projection
Neuron Projection
Synapse
Postsynaptic Membrane
Synaptic Membrane
Postsynaptic Density Membrane
Cornified Envelope
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Calpain Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Monoatomic Ion Channel Activity
Protein Binding
Zinc Ion Binding
Ligand-gated Monoatomic Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Metal Ion Binding
Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Metal Ion Binding
Biological Process
Monoatomic Ion Transport
Glutamate Receptor Signaling Pathway
Chemical Synaptic Transmission
Brain Development
Learning Or Memory
Calcium-mediated Signaling
Monoatomic Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Response To Ethanol
Regulation Of Synaptic Plasticity
Regulation Of Neuronal Synaptic Plasticity
Protein Heterotetramerization
Positive Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Calcium Ion Transmembrane Import Into Cytosol
Monoatomic Cation Transmembrane Transport
Excitatory Chemical Synaptic Transmission
Regulation Of Presynaptic Membrane Potential
Negative Regulation Of Dendritic Spine Maintenance
Regulation Of Monoatomic Cation Transmembrane Transport
Positive Regulation Of Excitatory Postsynaptic Potential
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Receptor Catabolic Process
Regulation Of Catalytic Activity
Mammary Gland Involution
Self Proteolysis
NMDA Selective Glutamate Receptor Signaling Pathway
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
MECP2 regulates neuronal receptors and channels
Activated NTRK2 signals through FYN
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Haloperidol
Dextropropoxyphene
Acamprosate
Donepezil
Guaifenesin
Felbamate
Memantine
Phenobarbital
Aripiprazole
Tenocyclidine
Prasterone
Taurine
Milnacipran
EVT-101
Lumateperone
Acetylcysteine
Ketobemidone
Gavestinel
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Esketamine
Fluciclovine (18F)
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS
Adventurousness (
30643258
)
Aging (time to event) (
21782286
)
Alzheimer's disease in hypertension (
31055733
)
Anxiety (
33859377
)
Brain structure (temporal lobe volume) (
20197096
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Cognitive performance (
19734545
)
Dietary fat liking (
32516399
)
Egg allergy (parent-of-origin effect) (
29489655
)
General risk tolerance (MTAG) (
30643258
)
Height (
31562340
)
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Keratoconus (
33649486
)
Major depressive disorder (
23377640
)
Opioid dependence (time to event) (
34124712
)
Ovarian reserve (
22116950
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors in depression (
30034349
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systolic blood pressure (
30224653
)
Total ventricular volume (
21116278
)
Waist-hip ratio (
28552196
)
Waist-to-hip ratio adjusted for BMI (
28552196
)
Urate levels (
31578528
)
Interacting Genes
45 interacting genes:
ACTN2
AP1M1
AP2M1
AP4M1
ARHGAP32
CAMK2A
CAMK2B
CAMK2D
CAMK2G
CAMK2N1
CAPN1
CSNK2A1
CSNK2A2
CSNK2B
DLG1
DLG2
DLG3
DLG4
EGFR
EPHB2
ERBIN
EXOC4
EXOC7
FYN
GRIN1
GRIN3A
IL16
LIN7A
LIN7B
MAGI3
MIB2
PATJ
PIK3CA
PLCG1
PRKCA
PRKCB
PRKCG
PRKN
PTPN11
RACK1
RASGRF1
SPTAN1
SRC
SYNGAP1
TANC1
55 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KCTD7
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
Entrez ID
2904
823
HPRD ID
00697
00253
Ensembl ID
ENSG00000273079
ENSG00000014216
Uniprot IDs
A0A8D9PHB2
Q13224
B2RDI5
B4DWH5
P07384
PDB IDs
5EWJ
5EWL
5EWM
7EU8
7KL0
7KL1
7KL2
7UIS
7UJP
7UJQ
7UJR
7UJS
7UJT
8VUU
8VUV
9D37
9D38
9D39
9D3A
9D3B
9D3C
1ZCM
2ARY
7W7O
7X79
8GX3
Enriched GO Terms of Interacting Partners
?
Postsynaptic Density
Neuron Projection
Regulation Of Protein Localization To Membrane
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Cellular Localization
Plasma Membrane
Cytosol
Regulation Of Protein Localization
Regulation Of Synaptic Plasticity
Learning Or Memory
Postsynaptic Density Membrane
Synapse
Regulation Of Biological Quality
Modulation Of Chemical Synaptic Transmission
Regulation Of Protein Localization To Plasma Membrane
Cognition
Calcium- And Calmodulin-dependent Protein Kinase Complex
Regulation Of Protein Localization To Cell Periphery
Kinase Activity
Protein Kinase Activity
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Junction
Positive Regulation Of Protein Localization To Membrane
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Synaptic Transmission
Signal Transduction
Regulation Of Transport
Protein Serine/threonine Kinase Activity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Ionotropic Glutamate Receptor Binding
Glutamatergic Synapse
Epidermal Growth Factor Receptor Signaling Pathway
Protein Kinase CK2 Complex
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Metal Ion Transport
Protein Serine Kinase Activity
Intracellular Signal Transduction
Endocytic Vesicle Membrane
ERBB Signaling Pathway
System Process
Regulation Of Monoatomic Ion Transport
Chemical Synaptic Transmission
Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Localization
MPP7-DLG1-LIN7 Complex
Organelle Organization
Regulation Of Programmed Cell Death
Response To Alcohol
Regulation Of Organelle Organization
Regulation Of Apoptotic Process
Identical Protein Binding
Positive Regulation Of Organelle Organization
Regulation Of Multicellular Organismal Process
Protease Binding
Cytoplasm
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Developmental Process
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Gene Expression
Response To Lipid
Positive Regulation Of Programmed Cell Death
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Negative Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Hepatocyte Apoptotic Process
Cytosol
Regulation Of Actin Filament Depolymerization
Negative Regulation Of Apoptotic Process
Cell Junction Maintenance
Regulation Of Renin Secretion Into Blood Stream
Regulation Of Autophagy
Sarcomere
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Filament-based Process
Regulation Of Mitochondrial Membrane Permeability
G-protein Beta-subunit Binding
Regulation Of Protein Localization
Response To Amino Acid
Release Of Cytochrome C From Mitochondria
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Response To Fluoride
Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Apoptotic Process
Cellular Component Maintenance
Regulation Of Membrane Permeability
Cysteine-type Peptidase Activity
Positive Regulation Of Cellular Component Organization
Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Protein Localization
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