GRIN2B and GRIN3A

Number of citations of the paper that reports this interaction (PMID 12391275)
12

Data Source:
HPRD (in vivo)

		GRIN2B	GRIN3A
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 2B	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Postsynaptic Membrane Neuronal Postsynaptic Density	Postsynaptic Density Membrane Integral Component Of Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Glycine Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Glycine Binding Neurotransmitter Binding Identical Protein Binding Protein Phosphatase 2A Binding
	Biological Process	Behavioral Fear Response In Utero Embryonic Development Startle Response Suckling Behavior Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Axon Guidance Sensory Organ Development Learning Or Memory Learning Memory Regulation Of Protein Kinase A Signaling Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport	Calcium Ion Transport Dendrite Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Rhythmic Process Prepulse Inhibition Calcium Ion Transmembrane Transport
Pathways		EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Meperidine Haloperidol Felbamate Memantine Tenocyclidine	L-Glutamic Acid Tramadol Methadone Ethopropazine Dextromethorphan Acamprosate Procaine Ethanol Amantadine Felbamate Memantine Halothane Chloroprocaine Orphenadrine Ketamine Tenocyclidine Rolicyclidine Phencyclidine
Diseases
GWAS		Aging (time to event) ( 21782286) Brain structure (temporal lobe volume) ( 20197096) Cognitive performance ( 19734545) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Total ventricular volume ( 21116278)	Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		40 interactors: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBB2IP EXOC4 EXOC7 FYN GNB2L1 GRIN1 GRIN3A IL16 INADL LIN7A LIN7B MAGI3 MIB2 PARK2 PIK3CA PLCG1 PRKCA PRKCB PRKCG PTPN11 SPTAN1 SRC SYNGAP1 TANC1	5 interactors: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B
Entrez ID		2904	116443
HPRD ID		00697	09443
Ensembl ID			ENSG00000198785
Uniprot IDs		Q13224	Q8TCU5
PDB IDs		1S11 1S2S 2IPV
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Signaling Cell Communication Axon Guidance Cell Projection Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Projection Development Receptor Localization To Synapse Regulation Of Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Axonogenesis Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Learning Response To Stimulus Neuron Projection Morphogenesis Nervous System Development Locomotion Fibroblast Growth Factor Receptor Signaling Pathway Learning Or Memory Response To External Stimulus Ephrin Receptor Signaling Pathway Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Synapse Protein Localization Receptor Clustering Cognition Blood Coagulation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Body Fluid Levels Cellular Response To Stimulus Hemostasis Platelet Activation	Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Depolarization Neuromuscular Process Learning Regulation Of Synaptic Plasticity Startle Response Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Learning Or Memory Regulation Of Membrane Potential Cognition Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Of Pain Single-organism Behavior Memory Synaptic Transmission Behavior Response To Ethanol Calcium Ion Transmembrane Transport Suckling Behavior Nervous System Development Cell-cell Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Response To Amphetamine Calcium Ion Transport Social Behavior Neurological System Process Positive Regulation Of Membrane Potential Locomotion Regulation Of Signaling Axon Guidance Response To Amine Regulation Of Neuronal Synaptic Plasticity Visual Learning Visual Behavior Axonogenesis Neurogenesis Associative Learning Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Ephrin Receptor Signaling Pathway Response To External Stimulus Feeding Behavior
Tagcloud ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?