GRIN2B and AP4M1

Number of citations of the paper that reports this interaction (PubMedID 15254094)
38

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GRIN2B	AP4M1
Description		glutamate ionotropic receptor NMDA type subunit 2B	adaptor related protein complex 4 subunit mu 1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Late Endosome Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Cell Projection Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Postsynaptic Density Membrane	Cytoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Protein Transmembrane Transporter Activity Protein Domain Specific Binding
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Negative Regulation Of Dendritic Spine Maintenance Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential	Autophagosome Assembly Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Transmembrane Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Activated NTRK2 signals through FYN Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Lysosome Vesicle Biogenesis
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Haloperidol Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Taurine Milnacipran EVT-101 Lumateperone Acetylcysteine Ketobemidone Gavestinel Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Esketamine Fluciclovine (18F)
Diseases			Cerebral palsy
GWAS		Adventurousness ( 30643258) Aging (time to event) ( 21782286) Alzheimer's disease in hypertension ( 31055733) Anxiety ( 33859377) Brain structure (temporal lobe volume) ( 20197096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cognitive performance ( 19734545) Dietary fat liking ( 32516399) Egg allergy (parent-of-origin effect) ( 29489655) General risk tolerance (MTAG) ( 30643258) Height ( 31562340) Immune reponse to smallpox (secreted IL-2) ( 22610502) Keratoconus ( 33649486) Major depressive disorder ( 23377640) Opioid dependence (time to event) ( 34124712) Ovarian reserve ( 22116950) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653) Total ventricular volume ( 21116278) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		45 interacting genes: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 EGFR EPHB2 ERBIN EXOC4 EXOC7 FYN GRIN1 GRIN3A IL16 LIN7A LIN7B MAGI3 MIB2 PATJ PIK3CA PLCG1 PRKCA PRKCB PRKCG PRKN PTPN11 RACK1 RASGRF1 SPTAN1 SRC SYNGAP1 TANC1	16 interacting genes: ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B HOOK1 HOOK2 KRTAP5-2 LAMP2 TGOLN2 USP47 ZBTB22
Entrez ID		2904	9179
HPRD ID		00697	03803
Ensembl ID		ENSG00000273079	ENSG00000221838
Uniprot IDs		A0A8D9PHB2 Q13224	C9JC87 C9JWL4 H7C0A0 O00189
PDB IDs		5EWJ 5EWL 5EWM 7EU8 7KL0 7KL1 7KL2 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 8VUU 8VUV 9D37 9D38 9D39 9D3A 9D3B 9D3C	3L81 4MDR
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Neuron Projection Regulation Of Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Regulation Of Cellular Localization Plasma Membrane Cytosol Regulation Of Protein Localization Regulation Of Synaptic Plasticity Learning Or Memory Postsynaptic Density Membrane Synapse Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Regulation Of Protein Localization To Plasma Membrane Cognition Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Localization To Cell Periphery Kinase Activity Protein Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Junction Positive Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Synaptic Transmission Signal Transduction Regulation Of Transport Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Glutamatergic Synapse Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Metal Ion Transport Protein Serine Kinase Activity Intracellular Signal Transduction Endocytic Vesicle Membrane ERBB Signaling Pathway System Process Regulation Of Monoatomic Ion Transport Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Positive Regulation Of Protein Localization MPP7-DLG1-LIN7 Complex	Postsynaptic Density Membrane Ligand-gated Monoatomic Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential FHF Complex Synaptic Transmission, Glutamatergic Intracellular Protein Localization Platelet Dense Granule Membrane Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Protein Localization To Perinuclear Region Of Cytoplasm Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Excitatory Chemical Synaptic Transmission Cellular Localization Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Ion Transmembrane Transport Calcium Ion Transport HOPS Complex Modulation Of Chemical Synaptic Transmission Somatodendritic Compartment Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Transport Lysosomal Transport Inorganic Cation Transmembrane Transport Early Endosome To Late Endosome Transport Monoatomic Cation Transmembrane Transport AMPA Glutamate Receptor Complex Dynein Light Intermediate Chain Binding Positive Regulation Of Synaptic Transmission Late Endosome Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Inorganic Ion Transmembrane Transport Protein Localization To Postsynapse Transmembrane Transport Monoatomic Ion Channel Activity Vacuolar Transport Monoatomic Cation Transport Trans-Golgi Network Mitotic Cleavage Furrow Ingression Pigment Granule Maturation Peptide Pheromone Maturation Chaperone-mediated Autophagy Translocation Complex Establishment Of Protein Localization
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