GRIN2B and PIK3CA

Number of citations of the paper that reports this interaction (PubMedID 10620012)
0

Data Source:
HPRD (in vivo, in vitro)

		GRIN2B	PIK3CA
Description		glutamate ionotropic receptor NMDA type subunit 2B	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Late Endosome Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Cell Projection Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Postsynaptic Density Membrane	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Intercalated Disc Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Zinc Ion Binding Ligand-gated Monoatomic Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Metal Ion Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Protein Kinase Activator Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Negative Regulation Of Dendritic Spine Maintenance Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential	Angiogenesis Liver Development Vasculature Development Glucose Metabolic Process Lipid Metabolic Process Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Response To Activity Response To Muscle Inactivity Negative Regulation Of Macroautophagy Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Response To Muscle Stretch Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Multicellular Organism Growth Response To L-leucine Anoikis Regulation Of Cellular Respiration Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Phosphatidylinositol Phosphate Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Adipose Tissue Development Cellular Response To Glucose Stimulus Cellular Response To Hydrostatic Pressure Response To Dexamethasone Cardiac Muscle Cell Contraction Energy Homeostasis Regulation Of Actin Filament Organization Autosome Genomic Imprinting Response To Butyrate Positive Regulation Of Protein Localization To Membrane Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Anoikis
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Activated NTRK2 signals through FYN Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Haloperidol Dextropropoxyphene Acamprosate Donepezil Guaifenesin Felbamate Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Taurine Milnacipran EVT-101 Lumateperone Acetylcysteine Ketobemidone Gavestinel Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Esketamine Fluciclovine (18F)	ATP Caffeine XL765 Wortmannin Pilaralisib Alpelisib Copanlisib
Diseases			Ovarian cancer
GWAS		Adventurousness ( 30643258) Aging (time to event) ( 21782286) Alzheimer's disease in hypertension ( 31055733) Anxiety ( 33859377) Brain structure (temporal lobe volume) ( 20197096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cognitive performance ( 19734545) Dietary fat liking ( 32516399) Egg allergy (parent-of-origin effect) ( 29489655) General risk tolerance (MTAG) ( 30643258) Height ( 31562340) Immune reponse to smallpox (secreted IL-2) ( 22610502) Keratoconus ( 33649486) Major depressive disorder ( 23377640) Opioid dependence (time to event) ( 34124712) Ovarian reserve ( 22116950) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653) Total ventricular volume ( 21116278) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		45 interacting genes: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 EGFR EPHB2 ERBIN EXOC4 EXOC7 FYN GRIN1 GRIN3A IL16 LIN7A LIN7B MAGI3 MIB2 PATJ PIK3CA PLCG1 PRKCA PRKCB PRKCG PRKN PTPN11 RACK1 RASGRF1 SPTAN1 SRC SYNGAP1 TANC1	69 interacting genes: ADAP1 AKT1 AMBP APLP2 APPL1 ARAF ATP5IF1 ATR BEX1 BEX2 CCND2 CSF1R CYTH2 CYTH3 DDX5 DNAJB6 EGFR FANCC FASLG FBP2 FTL GABRB1 GALNT12 GLIS2 GNAQ GRIN2B HRAS IL13RA2 IL24 IL3 IRS2 IRS4 ITIH1 KRAS LCK MAP2K1 MRAS MYC NEDD9 NRAS PDGFRA PDGFRB PDK1 PIK3R1 PIK3R3 PRKCD PSMC3IP PTPN11 RASD2 RASGRP3 RELA RPS20 RPS6KB1 SFRP4 SGK1 SH3KBP1 SMAD2 SMAD3 SNX9 SQSTM1 STAT1 STK11 THRSP TICAM1 TMOD1 TNFSF13 UFD1 UMPS VARS2
Entrez ID		2904	5290
HPRD ID		00697	01382
Ensembl ID		ENSG00000273079	ENSG00000121879
Uniprot IDs		A0A8D9PHB2 Q13224	P42336
PDB IDs		5EWJ 5EWL 5EWM 7EU8 7KL0 7KL1 7KL2 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 8VUU 8VUV 9D37 9D38 9D39 9D3A 9D3B 9D3C	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1 5XGH 5XGI 5XGJ 6GVF 6GVG 6GVH 6GVI 6NCT 6OAC 6PYS 6VO7 7JIU 7K6M 7K6N 7K6O 7K71 7L1B 7L1C 7L1D 7MLK 7MYN 7MYO 7PG5 7PG6 7R9V 7R9Y 7RRG 7TZ7 8AM0 8BFU 8DCP 8DCX 8DD4 8DD8 8EXL 8EXO 8EXU 8EXV 8GUA 8GUB 8GUD 8ILR 8ILS 8ILV 8OW2 8SBC 8SBJ 8TDU 8TGD 8TS7 8TS8 8TS9 8TSA 8TSB 8TSC 8TSD 8TU6 8TWY 8V8H 8V8I 8V8J 8V8U 8V8V 8VCL 8W9A 8W9B 9ASF 9ASG 9B4S 9B4T 9C15 9E8M
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Neuron Projection Regulation Of Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Regulation Of Cellular Localization Plasma Membrane Cytosol Regulation Of Protein Localization Regulation Of Synaptic Plasticity Learning Or Memory Postsynaptic Density Membrane Synapse Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Regulation Of Protein Localization To Plasma Membrane Cognition Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Localization To Cell Periphery Kinase Activity Protein Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Junction Positive Regulation Of Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Synaptic Transmission Signal Transduction Regulation Of Transport Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Glutamatergic Synapse Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Metal Ion Transport Protein Serine Kinase Activity Intracellular Signal Transduction Endocytic Vesicle Membrane ERBB Signaling Pathway System Process Regulation Of Monoatomic Ion Transport Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Positive Regulation Of Protein Localization MPP7-DLG1-LIN7 Complex	Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity Intracellular Signaling Cassette Regulation Of Apoptotic Process Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Cytosol Kinase Activity Positive Regulation Of D-glucose Import Cytoplasm Cell Population Proliferation Regulation Of Protein Localization To Cell Periphery Response To UV Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of D-glucose Transmembrane Transport Cell Migration Nucleotide Binding Negative Regulation Of Programmed Cell Death Response To Radiation Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Phospholipase C Activator Activity MAPK Cascade Response To Hormone Protein Kinase Binding Regulation Of Protein Modification Process Cell Motility Response To Growth Factor Response To Light Stimulus Negative Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of D-glucose Import Positive Regulation Of Gene Expression Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Positive Regulation Of Metabolic Process
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