SIAH1 and FZD9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SIAH1	FZD9
Description		siah E3 ubiquitin protein ligase 1	frizzled class receptor 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex	Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Membrane Filopodium Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt Receptor Activity Protein Heterodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ossification Release Of Cytochrome C From Mitochondria Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory Wnt Signaling Pathway B Cell Differentiation Positive Regulation Of Bone Mineralization Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Cycle Negative Regulation Of Mitochondrial Depolarization Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Bone Regeneration Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)	HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lamb consumption ( 32066663) Malaria ( 31844061) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Protein C levels ( 28082259)
Interacting Genes		157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	6 interacting genes: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A
Entrez ID		6477	8326
HPRD ID		03736	03460
Ensembl ID		ENSG00000196470	ENSG00000188763
Uniprot IDs		Q8IUQ4	O00144
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L
Enriched GO Terms of Interacting Partners?		Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process	Canonical Wnt Signaling Pathway Frizzled Binding Wnt Signaling Pathway Cell Proliferation In Midbrain Axis Specification Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Receptor Ligand Activity Central Nervous System Neuron Differentiation Cell Fate Commitment Anatomical Structure Morphogenesis Cytokine Activity Embryonic Axis Specification Dopaminergic Neuron Differentiation Positive Regulation Of Fibroblast Proliferation Neuron Differentiation Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Specification Process Cell Differentiation Signaling Receptor Binding Response To Transforming Growth Factor Beta Embryonic Morphogenesis Endocytic Vesicle Membrane Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Regulation Of Embryonic Development Asymmetric Protein Localization Involved In Cell Fate Determination Regulation Of Fibroblast Proliferation Golgi Lumen Cellular Developmental Process Central Nervous System Morphogenesis Neurogenesis Diencephalon Development Positive Regulation Of Protein Localization To Presynapse Postsynapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Lung Induction Oviduct Development Regulation Of JNK Cascade Embryonic Organ Development Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Population Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
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