SIAH1 and GRM5

Number of citations of the paper that reports this interaction (PubMedID 23152621)
32

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIAH1	GRM5
Description		siah E3 ubiquitin protein ligase 1	glutamate metabotropic receptor 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex	Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Astrocyte Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity A2A Adenosine Receptor Binding Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Positive Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Calcium-mediated Signaling Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Amyloid-beta
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs			Acamprosate ADX10059 Rufinamide Dipraglurant
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)	Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Depression ( 33859377) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Retinal detachment ( 31816047) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 30664655 31315583) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)
Interacting Genes		157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	20 interacting genes: ACTN1 CALM1 CALM2 CALM3 CAMK2A EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN
Entrez ID		6477	2915
HPRD ID		03736	04980
Ensembl ID		ENSG00000196470	ENSG00000168959
Uniprot IDs		Q8IUQ4	A8K5P7 P41594
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L	3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52 7FD8 7FD9 8T6J 8T7H 8T8M 8TAO 8X0B 8X0C 8X0D 8X0E 8X0F 8X0G 8X0H
Enriched GO Terms of Interacting Partners?		Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process	Diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Long-term Synaptic Potentiation Modulation Of Chemical Synaptic Transmission Regulation Of Transport Presynaptic Cytosol Positive Regulation Of Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Regulation Of Signal Transduction Regulation Of Metal Ion Transport Protein Serine Kinase Activity Regulation Of Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Protein Kinase C Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Protein Kinase Activity Regulation Of Biological Quality Plasma Membrane Regulation Of Synaptic Plasticity Negative Regulation Of Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Kinase Activity Calcium Channel Regulator Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Sequestering Of Calcium Ion Titin Binding Regulation Of Platelet Activation Cytoplasm Sarcomere Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Histone H3T6 Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Monoatomic Ion Transmembrane Transport
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