SIAH1 and PFKM

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SIAH1	PFKM
Description		siah E3 ubiquitin protein ligase 1	phosphofructokinase, muscle
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GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane Sperm Principal Piece
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Phosphofructokinase Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Glycogen Catabolic Process Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Insulin Secretion Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Glycolysis
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)	Glycated hemoglobin levels ( 34059833) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	20 interacting genes: ATP6V0A4 CAV3 CEBPA DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		6477	5213
HPRD ID		03736	01988
Ensembl ID		ENSG00000196470	ENSG00000152556
Uniprot IDs		Q8IUQ4	A0A024R0Y5 A0A0S2Z4I1 A0A2R8Y891 F8VTQ3 P08237
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L	4OMT
Enriched GO Terms of Interacting Partners?		Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process	Caveola Regulation Of Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Trabecula Formation Negative Regulation Of Signaling Negative Regulation Of Transport Negative Regulation Of Cell Communication Negative Regulation Of Potassium Ion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Z Disc Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Development Myoblast Fusion Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hematopoietic Stem Cell Proliferation Response To Hormone Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Wnt-protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Cellular Developmental Process Sodium Channel Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Membrane Repolarization T-tubule Cardiac Muscle Cell Development Regulation Of Sodium Ion Transmembrane Transport Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Proteolysis Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Signal Transduction Negative Regulation Of Sarcomere Organization Cell-cell Fusion Regulation Of Signal Transduction By Receptor Internalization Cardiac Cell Development Syncytium Formation Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Population Proliferation Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Response To Dexamethasone Positive Regulation Of Macromolecule Biosynthetic Process PCNA Complex
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