SIAH1 and NUMB

  • Number of citations of the paper that reports this interaction (PMID 11752454)
  • 20
  • Data Source:
  • HPRD (two hybrid, in vitro, in vivo)

SIAH1

NUMB

Gene Name siah E3 ubiquitin protein ligase 1 numb homolog (Drosophila)
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Bipolar disorder (mood-incongruent) ( 23092984)
  • Coronary artery calcification ( 17903303)
Protein-Protein Interactions 135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1
Entrez ID 6477 8650
HPRD ID 03736 04767
Ensembl ID ENSG00000196470 ENSG00000133961
Uniprot IDs Q8IUQ4 P49757
PDB IDs 2A25 4I7B 4I7C 4I7D
Enriched GO Terms of Interacting Partners?
Tagcloud ?
alleviates  anticancer  appears  cytotoxicity  debatable  decreases  degradation  demonstrating  downregulation  e3  exerts  increases  inducing  inhibiting  introduce  ligase  note  oncoprotein  p34sei  partly  polyubiquitination  prerequisite  previous  reveal  stronger  summary  ubiquitin  view  vitamin 
adapter  affinities  arise  asymmetric  bind  bond  contain  diverse  division  domain  gp  gppy  helical  hydrogen  ldnpay  library  lnx  modes  motif  nak  nmr  npxy  peptide  phosphotyrosine  ptb  reveals  sheet  turn  y 
Tagcloud (Difference) ?
alleviates  anticancer  appears  cytotoxicity  debatable  decreases  degradation  demonstrating  downregulation  e3  exerts  increases  inducing  inhibiting  introduce  ligase  note  oncoprotein  p34sei  partly  polyubiquitination  prerequisite  previous  reveal  stronger  summary  ubiquitin  view  vitamin 
adapter  affinities  arise  asymmetric  bind  bond  contain  diverse  division  domain  gp  gppy  helical  hydrogen  ldnpay  library  lnx  modes  motif  nak  nmr  npxy  peptide  phosphotyrosine  ptb  reveals  sheet  turn  y 
Tagcloud (Intersection) ?