SIAH1 and USP19

Number of citations of the paper that reports this interaction (PMID 23500468)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIAH1	USP19
Gene Name		siah E3 ubiquitin protein ligase 1	ubiquitin specific peptidase 19
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Deubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress Negative Regulation Of Skeletal Muscle Tissue Development Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671	13 interactors: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 UBC
Entrez ID		6477	10869
HPRD ID		03736	18278
Ensembl ID		ENSG00000196470	ENSG00000172046
Uniprot IDs		Q8IUQ4	O94966
PDB IDs		2A25 4I7B 4I7C 4I7D	1WH0
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Apoptotic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Innate Immune Response Protein Ubiquitination Protein K48-linked Ubiquitination Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Defense Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune Response Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Immune System Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Cellular Response To Stress Cellular Response To Organic Substance Response To Cytokine Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Stimulus Regulation Of Chromosome Organization	Cell Morphogenesis Involved In Differentiation Cell Cycle Epithelial To Mesenchymal Transition Protein Ubiquitination Cell Morphogenesis Protein Modification By Small Protein Conjugation MRNA Transcription From RNA Polymerase II Promoter MRNA Transcription Positive Regulation Of Signal Transduction Mesenchymal Cell Development Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Mesenchymal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Anatomical Structure Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Mesenchyme Development Regulation Of Intracellular Signal Transduction Regulation Of Nitric-oxide Synthase Activity Cell Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signal Transduction Stem Cell Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Mitotic Cell Cycle Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of TOR Signaling Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Stem Cell Differentiation Neural Fold Elevation Formation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Oxidoreductase Activity Cell Projection Morphogenesis Toll-like Receptor 4 Signaling Pathway Regulation Of Catalytic Activity Cell Differentiation Regulation Of Cell Death Cell Part Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process
Tagcloud ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	adenoviral catalytic chop collectively concomitant creating defect deubiquitinating display enhancement exerts fusion implicate isoform isoforms l6 localized modulated modulates muscle myoblast myofibrillar myogenin possibility raised regeneration thapsigargin unfolded upr
Tagcloud (Difference) ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	adenoviral catalytic chop collectively concomitant creating defect deubiquitinating display enhancement fusion implicate isoform isoforms l6 localized modulated modulates muscle myoblast myofibrillar myogenin possibility raised regeneration thapsigargin unfolded upr
Tagcloud (Intersection) ?		exerts