SIAH1 and AFF1

Number of citations of the paper that reports this interaction (PMID 15221006)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		SIAH1	AFF1
Gene Name		siah E3 ubiquitin protein ligase 1	AF4/FMR2 family, member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Transcription Elongation Factor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Transcription, DNA-templated
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 22291604) Triglycerides ( 20864672 20686565)
Protein-Protein Interactions		135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671	7 interactors: HIST3H3 MLLT1 MLLT3 NT5E SIAH1 SIAH2 SMAD9
Entrez ID		6477	4299
HPRD ID		03736	08871
Ensembl ID		ENSG00000196470	ENSG00000172493
Uniprot IDs		Q8IUQ4	P51825 Q14C88
PDB IDs		2A25 4I7B 4I7C 4I7D	2LM0
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Apoptotic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Innate Immune Response Protein Ubiquitination Protein K48-linked Ubiquitination Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Defense Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune Response Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Immune System Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Cellular Response To Stress Cellular Response To Organic Substance Response To Cytokine Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Stimulus Regulation Of Chromosome Organization	Adenosine Biosynthetic Process AMP Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Purine Nucleoside Monophosphate Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mullerian Duct Regression Cellular Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Purine Ribonucleoside Catabolic Process Nucleobase-containing Compound Metabolic Process AMP Metabolic Process Adenosine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Segment Specification Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axon Guidance Anatomical Structure Regression Pyrimidine Nucleoside Catabolic Process Cellular Nitrogen Compound Metabolic Process Protein Destabilization Purine Ribonucleotide Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nitrogen Compound Metabolic Process
Tagcloud ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Intersection) ?