HK3 and ZBTB17

Number of citations of the paper that reports this interaction (PubMedID 11068878)
0

Data Source:
HPRD (in vitro, two hybrid)

		HK3	ZBTB17
Description		hexokinase 3	zinc finger and BTB domain containing 17
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GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Hexose Metabolic Process Organophosphate Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Cytokine Production Regulation Of Immune System Process Ectoderm Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G1 To G0 Transition
Pathways		Neutrophil degranulation Glycolysis	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Uterine fibroids ( 30194396) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Erectile dysfunction ( 30583798) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Idiopathic dilated cardiomyopathy ( 21459883)
Interacting Genes		10 interacting genes: ATF4 GRN HPGDS IGFBP4 LEP MEOX2 MITF PPP2CB PTGDS ZBTB17	28 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 VHL ZBTB7C ZBTB8A
Entrez ID		3101	7709
HPRD ID		00806	04968
Ensembl ID		ENSG00000160883	ENSG00000116809
Uniprot IDs		P52790	Q13105 Q53EM1
PDB IDs		3HM8	2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION 7AZW 7AZX 7MC1 7MC2 7MC3 7T58
Enriched GO Terms of Interacting Partners?		Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Regulation Of Multicellular Organismal Process Insulin-like Growth Factor I Binding Regulation Of Cell Population Proliferation Prostaglandin Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Prostanoid Biosynthetic Process Tissue Development Response To Leptin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Small Molecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Aorta Development Prostaglandin Metabolic Process Prostanoid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Embryo Implantation Artery Development Response To Endoplasmic Reticulum Stress Bone Mineralization Regulation Of Growth Positive Regulation Of Aspartic-type Peptidase Activity Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Response To Hormone Negative Regulation Of Glutamine Transport Regulation Of Metabolic Process Positive Regulation Of Neuron Apoptotic Process ATF1-ATF4 Transcription Factor Complex Organic Acid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Metabolic Process Response To Hypoxia Carboxylic Acid Metabolic Process CHOP-ATF4 Complex DNA-binding Transcription Factor Activity Response To Decreased Oxygen Levels Regulation Of Developmental Growth Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Metabolic Process Response To Vitamin Regulation Of Fat Cell Apoptotic Process Folate Import Across Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Estrogen Response Element Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Decreased Oxygen Levels Chromatin Chromatin Remodeling Regulation Of Gene Expression Response To Oxygen Levels Regulation Of Macromolecule Biosynthetic Process Histone H3K27 Acetyltransferase Activity Myc-Max Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Steroid Receptor Activity Morphogenesis Of A Branching Structure Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process
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