HK3 and PTGDS

Number of citations of the paper that reports this interaction (PubMedID 11068878)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HK3	PTGDS
Description		hexokinase 3	prostaglandin D2 synthase
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Isomerase Activity Small Molecule Binding
	Biological Process	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Hexose Metabolic Process Organophosphate Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Gene Expression Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep Prostanoid Biosynthetic Process Response To Glucocorticoid Negative Regulation Of Male Germ Cell Proliferation
Pathways		Neutrophil degranulation Glycolysis	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation
Drugs			Vitamin A
Diseases
GWAS		Uterine fibroids ( 30194396) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Beta-trace protein levels ( 23328707) Corneal structure ( 23291589) Keratoconus ( 33649486)
Interacting Genes		10 interacting genes: ATF4 GRN HPGDS IGFBP4 LEP MEOX2 MITF PPP2CB PTGDS ZBTB17	23 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR GGA3 HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2
Entrez ID		3101	5730
HPRD ID		00806	08904
Ensembl ID		ENSG00000160883	ENSG00000107317
Uniprot IDs		P52790	A0A024R8G3 P41222
PDB IDs		3HM8	2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9 8HTA
Enriched GO Terms of Interacting Partners?		Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Regulation Of Multicellular Organismal Process Insulin-like Growth Factor I Binding Regulation Of Cell Population Proliferation Prostaglandin Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Prostanoid Biosynthetic Process Tissue Development Response To Leptin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Small Molecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Aorta Development Prostaglandin Metabolic Process Prostanoid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Embryo Implantation Artery Development Response To Endoplasmic Reticulum Stress Bone Mineralization Regulation Of Growth Positive Regulation Of Aspartic-type Peptidase Activity Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Response To Hormone Negative Regulation Of Glutamine Transport Regulation Of Metabolic Process Positive Regulation Of Neuron Apoptotic Process ATF1-ATF4 Transcription Factor Complex Organic Acid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Metabolic Process Response To Hypoxia Carboxylic Acid Metabolic Process CHOP-ATF4 Complex DNA-binding Transcription Factor Activity Response To Decreased Oxygen Levels Regulation Of Developmental Growth Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Metabolic Process Response To Vitamin Regulation Of Fat Cell Apoptotic Process Folate Import Across Plasma Membrane	Regulation Of Macroautophagy Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Hexokinase Activity Glucokinase Activity Fructokinase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Prostaglandin E Receptor Activity Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Nitric-oxide Synthase Regulator Activity D1 Dopamine Receptor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Catabolic Process Excitatory Postsynaptic Potential D-glucose Binding Catabolic Process Regulation Of Autophagy Regulation Of Protein Catabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor Establishment Of Protein Localization To Mitochondrion Response To UV-A Enzyme Binding Fructose 6-phosphate Metabolic Process Positive Regulation Of Protein Catabolic Process Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Identical Protein Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Postsynaptic Membrane Potential Response To Alcohol Macromolecule Catabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Peptidyl-serine Phosphorylation Glycolytic Process Through Glucose-6-phosphate Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Keratin Filament Positive Regulation Of DNA Metabolic Process Positive Regulation Of Protein Metabolic Process Ficolin-1-rich Granule Lumen Positive Regulation Of Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway
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