HK3 and PPP2CB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HK3	PPP2CB
Description		hexokinase 3	protein phosphatase 2 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton FAR/SIN/STRIPAK Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Transmembrane Transporter Binding Metal Ion Binding Tau Protein Binding
	Biological Process	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Hexose Metabolic Process Organophosphate Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process	Mitotic Cell Cycle Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Microtubule Polymerization Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Regulation Of Neurofibrillary Tangle Assembly
Pathways		Neutrophil degranulation Glycolysis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs			Vitamin E
Diseases
GWAS		Uterine fibroids ( 30194396) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Daytime sleep phenotypes ( 27126917) Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		10 interacting genes: ATF4 GRN HPGDS IGFBP4 LEP MEOX2 MITF PPP2CB PTGDS ZBTB17	41 interacting genes: ACP5 AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B UBC ZFP28 ZNF775
Entrez ID		3101	5516
HPRD ID		00806	01487
Ensembl ID		ENSG00000160883	ENSG00000104695
Uniprot IDs		P52790	A0A140VJS0 P62714
PDB IDs		3HM8
Enriched GO Terms of Interacting Partners?		Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Regulation Of Multicellular Organismal Process Insulin-like Growth Factor I Binding Regulation Of Cell Population Proliferation Prostaglandin Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Prostanoid Biosynthetic Process Tissue Development Response To Leptin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Small Molecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Aorta Development Prostaglandin Metabolic Process Prostanoid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Embryo Implantation Artery Development Response To Endoplasmic Reticulum Stress Bone Mineralization Regulation Of Growth Positive Regulation Of Aspartic-type Peptidase Activity Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Response To Hormone Negative Regulation Of Glutamine Transport Regulation Of Metabolic Process Positive Regulation Of Neuron Apoptotic Process ATF1-ATF4 Transcription Factor Complex Organic Acid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Metabolic Process Response To Hypoxia Carboxylic Acid Metabolic Process CHOP-ATF4 Complex DNA-binding Transcription Factor Activity Response To Decreased Oxygen Levels Regulation Of Developmental Growth Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Metabolic Process Response To Vitamin Regulation Of Fat Cell Apoptotic Process Folate Import Across Plasma Membrane	Intracellular Signal Transduction Mismatch Repair Complex Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Response To Growth Factor MAPK Cascade Kinase Activity Mismatched DNA Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Enzyme Binding Chiasma Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Cytosol Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MutLalpha Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Protein Phosphorylation ATP Binding Immune Response-activating Signaling Pathway Regulation Of Neurogenesis Regulation Of MAPK Cascade Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Morphogenesis Of A Branching Epithelium Positive Regulation Of Immune Response Positive Regulation Of Protein Modification Process Animal Organ Morphogenesis Anatomical Structure Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Developmental Process Phosphorylation Gland Morphogenesis Morphogenesis Of A Branching Structure Mismatch Repair Cell Development Nucleotide Binding Negative Regulation Of Cellular Component Organization Transferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?