HK3 and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 11068878)
0

Data Source:
HPRD (two hybrid, in vitro)

		HK3	HPGDS
Description		hexokinase 3	hematopoietic prostaglandin D synthase
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Transferase Activity Isomerase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Hexose Metabolic Process Organophosphate Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Response To Nematode Response To Selenium Ion Negative Regulation Of Male Germ Cell Proliferation
Pathways		Neutrophil degranulation Glycolysis	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide Deoxycholic acid 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Uterine fibroids ( 30194396) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		10 interacting genes: ATF4 GRN HPGDS IGFBP4 LEP MEOX2 MITF PPP2CB PTGDS ZBTB17	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		3101	27306
HPRD ID		00806	04001
Ensembl ID		ENSG00000160883	ENSG00000163106
Uniprot IDs		P52790	A0A384P5J0 O60760
PDB IDs		3HM8	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H 6ZTC 7JR6 7JR8
Enriched GO Terms of Interacting Partners?		Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Regulation Of Germ Cell Proliferation Regulation Of Multicellular Organismal Process Insulin-like Growth Factor I Binding Regulation Of Cell Population Proliferation Prostaglandin Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Prostanoid Biosynthetic Process Tissue Development Response To Leptin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Small Molecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Aorta Development Prostaglandin Metabolic Process Prostanoid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Embryo Implantation Artery Development Response To Endoplasmic Reticulum Stress Bone Mineralization Regulation Of Growth Positive Regulation Of Aspartic-type Peptidase Activity Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Response To Hormone Negative Regulation Of Glutamine Transport Regulation Of Metabolic Process Positive Regulation Of Neuron Apoptotic Process ATF1-ATF4 Transcription Factor Complex Organic Acid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Metabolic Process Response To Hypoxia Carboxylic Acid Metabolic Process CHOP-ATF4 Complex DNA-binding Transcription Factor Activity Response To Decreased Oxygen Levels Regulation Of Developmental Growth Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Metabolic Process Response To Vitamin Regulation Of Fat Cell Apoptotic Process Folate Import Across Plasma Membrane	Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heat Generation Hexokinase Activity Mannokinase Activity Glucokinase Activity Fructokinase Activity Leukemia Inhibitory Factor Signaling Pathway Leukemia Inhibitory Factor Receptor Binding Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Beta-3 Adrenergic Receptor Binding Negative Regulation Of Protein Localization To Microtubule Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Meiotic DNA Double-strand Break Processing Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Postsynaptic Recycling Endosome Membrane Protein Depalmitoylation Positive Regulation Of Protein Metabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Cell Adhesion Muscle Organ Morphogenesis Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Lung Lobe Morphogenesis Positive Regulation Of Plasminogen Activation Guanyl-nucleotide Exchange Factor Complex Regulation Of Locomotion Involved In Locomotory Behavior Heat Generation Central Element
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