CDK9 and AFF4

Number of citations of the paper that reports this interaction (PubMedID 12065898)
0

Data Source:
HPRD (in vitro)

		CDK9	AFF4
Description		cyclin dependent kinase 9	ALF transcription elongation factor 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane PML Body Cytoplasmic Ribonucleoprotein Granule P-TEFb Complex	Euchromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex Nuclear Body Super Elongation Complex
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Transcription Elongation Factor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity SnRNA Binding Protein Kinase Binding 7SK SnRNA Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Protein Phosphorylation DNA Damage Response Regulation Of Mitotic Cell Cycle Cell Population Proliferation Replication Fork Processing Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Nucleus Localization Regulation Of Cell Cycle Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin Transcription Elongation-coupled Chromatin Remodeling Transcription Pausing By RNA Polymerase II	Spermatid Development Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs		Alvocidib Seliciclib Trilaciclib Zotiraciclib
Diseases
GWAS		Body mass index ( 26426971)	A body shape index ( 34021172) Asthma ( 31619474) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		60 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CEBPA CTDP1 CTDSPL CUL1 DHX30 EAF1 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST LBX2 MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 OGT PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 STUB1 SUPT5H TAF7 TARBP2 TP53 TRAF2 UBE2A ZMYM6	10 interacting genes: AP2B1 BTG3 CCNT1 CDK9 GOLGA2 LRRK2 MLLT1 SIAH1 SPP1 TRAF2
Entrez ID		1025	27125
HPRD ID		16016	09187
Ensembl ID		ENSG00000136807	ENSG00000072364
Uniprot IDs		P50750	Q9UHB7
PDB IDs		3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R	4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Protein Modification Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process RNA Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Negative Regulation Of DNA-templated Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signal Transduction	P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Transcription Elongation Factor Complex Protein Kinase Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Clathrin Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury TORC2 Complex Disassembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Modification Process Negative Regulation Of Catabolic Process Positive Regulation Of Estradiol Secretion TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Protein Modification Process Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Side Of Plasma Membrane Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagy Canonical Wnt Signaling Pathway Regulation Of Estradiol Secretion Positive Regulation Of Protein Autoubiquitination Response To Curcumin Signal Sequence Binding Chromatin Binding Regulation Of Protein Serine/threonine Kinase Activity
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