CDK9 and AFF4

Number of citations of the paper that reports this interaction (PMID 12065898)
17

Data Source:
HPRD (in vitro)

		CDK9	AFF4
Gene Name		cyclin-dependent kinase 9	AF4/FMR2 family, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Positive Transcription Elongation Factor Complex B Membrane PML Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Mitochondrion Transcription Elongation Factor Complex Transcriptionally Active Chromatin
	Molecular Function	DNA Binding Chromatin Binding Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity SnRNA Binding Transcription Regulatory Region DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Gene Expression Viral Process Regulation Of Histone Modification Replication Fork Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Spermatid Development
Pathways		Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		56 interactors: ACTL6A AFF4 AR BCL10 BRCA1 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CTD CTDP1 CTDSPL CUL1 DHX30 FBXO25 GRN GTF2F1 HEXIM1 HEXIM2 HIST2H2BE HLTF HSPA1A HTATSF1 IL6ST MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6	9 interactors: AP2B1 CCNT1 CDK9 GOLGA2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2
Entrez ID		1025	27125
HPRD ID		16016	09187
Ensembl ID		ENSG00000136807	ENSG00000072364
Uniprot IDs		P50750	Q9UHB7
PDB IDs		1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY	4IMY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Phosphorylation Regulation Of Protein Phosphorylation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Biosynthetic Process Regulation Of Viral Transcription Cell Cycle Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Stimulus Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle	Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Replication Fork Arrest Response To Organic Substance Viral Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Collateral Sprouting Negative Regulation Of Glial Cell Apoptotic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Axon Regeneration Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Protein Homodimerization Activity Regulation Of Protein Metabolic Process Cellular Response To Nitric Oxide Regulation Of Protein Phosphorylation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Adhesion Regulation Of Protein Homodimerization Activity Locomotion Axon Guidance Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Arrest Cell Cycle
Tagcloud ?		affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb
Tagcloud (Difference) ?		affects associate bulk ccnk cdk12 cdk13 cdks ctd far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged	af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes
Tagcloud (Intersection) ?		elongation tefb