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CDK9 and SKP1
Number of citations of the paper that reports this interaction (PubMedID
11689688
)
52
Data Source:
BioGRID
(pull down, affinity chromatography technology)
CDK9
SKP1
Description
cyclin dependent kinase 9
S-phase kinase associated protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Transcription Elongation Factor Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Membrane
PML Body
Cytoplasmic Ribonucleoprotein Granule
P-TEFb Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Molecular Function
Nucleotide Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Transcription Elongation Factor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
SnRNA Binding
Protein Kinase Binding
7SK SnRNA Binding
Protein Serine Kinase Activity
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
Molecular Function Activator Activity
Ubiquitin Ligase Complex Scaffold Activity
F-box Domain Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
DNA Repair
Regulation Of DNA Repair
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Transcription Elongation By RNA Polymerase II
Protein Phosphorylation
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Replication Fork Processing
Regulation Of MRNA 3'-end Processing
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Host-mediated Activation Of Viral Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Muscle Cell Differentiation
Nucleus Localization
Regulation Of Cell Cycle
Cellular Response To Cytokine Stimulus
Negative Regulation Of Protein Localization To Chromatin
Positive Regulation Of Protein Localization To Chromatin
Transcription Elongation-coupled Chromatin Remodeling
Transcription Pausing By RNA Polymerase II
Protein Polyubiquitination
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Location In Nucleus
Axon Development
Protein K48-linked Ubiquitination
Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Drugs
Alvocidib
Seliciclib
Trilaciclib
Zotiraciclib
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
GWAS
Body mass index (
26426971
)
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
26502338
27399966
)
Interacting Genes
60 interacting genes:
ACTL6A
AFF4
AR
BCL10
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CEBPA
CTDP1
CTDSPL
CUL1
DHX30
EAF1
EEF1D
FBXO25
GRN
GTF2F1
H2BC21
HEXIM1
HEXIM2
HLTF
HSPA1A
HTATSF1
IL6ST
LBX2
MBP
MDFIC
MED21
MYBL2
NBN
NFKB1
NR2E3
OGT
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
STUB1
SUPT5H
TAF7
TARBP2
TP53
TRAF2
UBE2A
ZMYM6
75 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CFLAR
CKS1B
CUL1
CUL7
DDX19B
FBH1
FBXL2
FBXL20
FBXL3
FBXL4
FBXL5
FBXL8
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
Entrez ID
1025
6500
HPRD ID
16016
03255
Ensembl ID
ENSG00000136807
ENSG00000113558
Uniprot IDs
P50750
P63208
PDB IDs
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
6W9E
6Z45
7NWK
8I0L
8K5R
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
7B5L
7B5M
7B5R
7T1Y
7T1Z
7Z8B
7Z8T
7Z8V
7ZBW
7ZBZ
8BYA
8BYL
8CDJ
8CDK
8OR0
8OR3
8OR4
8S7D
8S7E
8UA6
8UBT
8UBU
9CB3
9JKB
9KBD
9KBF
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Nucleus
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of DNA-templated Transcription Elongation
Nucleobase-containing Compound Metabolic Process
Macromolecule Biosynthetic Process
Transcription By RNA Polymerase II
Regulation Of Protein Modification Process
Transcription Regulator Complex
Positive Regulation Of MiRNA Metabolic Process
RNA Metabolic Process
Cyclin/CDK Positive Transcription Elongation Factor Complex
7SK SnRNA Binding
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Coactivator Binding
Regulation Of MiRNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Protein-containing Complex
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Polyubiquitination
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Intracellular Signal Transduction
SCF Ubiquitin Ligase Complex
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Protein Catabolic Process
Protein Catabolic Process
Post-translational Protein Modification
Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Modification Process
Ubiquitin Ligase Complex
Ubiquitin-like Ligase-substrate Adaptor Activity
Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Catabolic Process
Regulation Of Cell Cycle
Ubiquitin Protein Ligase Binding
Cytosol
Ubiquitin-protein Transferase Activity
Cullin-RING Ubiquitin Ligase Complex
Cytoplasm
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Glycoprotein Catabolic Process
Regulation Of DNA Metabolic Process
Cul7-RING Ubiquitin Ligase Complex
Positive Regulation Of DNA Metabolic Process
Protein K48-linked Ubiquitination
Ubiquitin Protein Ligase Activity
Regulation Of Cell Cycle Process
Regulation Of Protein Stability
Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Protein Binding
Regulation Of Protein Ubiquitination
Cellular Response To Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Metabolic Process
TORC1 Signaling
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