CDK9 and UBE2A

Number of citations of the paper that reports this interaction (PubMedID 22592529)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		CDK9	UBE2A
Description		cyclin dependent kinase 9	ubiquitin conjugating enzyme E2 A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane PML Body Cytoplasmic Ribonucleoprotein Granule P-TEFb Complex	Chromatin Nucleoplasm Lysosome Endosome Late Endosome Cytosol HULC Complex
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Transcription Elongation Factor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity SnRNA Binding Protein Kinase Binding 7SK SnRNA Binding Protein Serine Kinase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Protein Phosphorylation DNA Damage Response Regulation Of Mitotic Cell Cycle Cell Population Proliferation Replication Fork Processing Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Nucleus Localization Regulation Of Cell Cycle Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin Transcription Elongation-coupled Chromatin Remodeling Transcription Pausing By RNA Polymerase II	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cytoplasmic Translation DNA Repair Postreplication Repair Chromatin Organization Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To UV Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Mitophagy
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Alvocidib Seliciclib Trilaciclib Zotiraciclib
Diseases
GWAS		Body mass index ( 26426971)	Brain connectivity ( 23471985)
Interacting Genes		60 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CEBPA CTDP1 CTDSPL CUL1 DHX30 EAF1 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST LBX2 MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 OGT PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 STUB1 SUPT5H TAF7 TARBP2 TP53 TRAF2 UBE2A ZMYM6	32 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 H2BC3 HECTD3 HLTF KCMF1 MDM2 PCNA PRKN PSMG1 RAD18 RC3H1 RNF167 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBA6 UBC UBR1 UBR3 UBR5 ZMYM2
Entrez ID		1025	7319
HPRD ID		16016	02422
Ensembl ID		ENSG00000136807	ENSG00000077721
Uniprot IDs		P50750	A0A0D9SG71 P49459
PDB IDs		3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R	6CYO 6CYR 8BTL 8IEJ
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Protein Modification Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process RNA Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Negative Regulation Of DNA-templated Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signal Transduction	Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Cellular Response To Stress Macromolecule Catabolic Process Transferase Activity DNA Damage Response Proteolysis Catabolic Process Chromatin Organization Protein K63-linked Ubiquitination Macromolecule Metabolic Process Response To Stress Nucleoplasm PML Body Zinc Ion Binding Ubiquitin Protein Ligase Binding Chromatin Remodeling Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Nucleus DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Hydrogen Peroxide Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription P53 Binding Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Activity Cellular Response To Actinomycin D Ubiquitin Activating Enzyme Activity Negative Regulation Of DNA-templated Transcription
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