CDK9 and NBN

Number of citations of the paper that reports this interaction (PubMedID 30179224)
83

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CDK9	NBN
Description		cyclin dependent kinase 9	nibrin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane PML Body Cytoplasmic Ribonucleoprotein Granule P-TEFb Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Golgi Apparatus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body BRCA1-C Complex Chromosomal Region
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Transcription Elongation Factor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity SnRNA Binding Protein Kinase Binding 7SK SnRNA Binding Protein Serine Kinase Activity	Damaged DNA Binding Protein Binding Histone Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding DNA-binding Transcription Factor Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Protein Phosphorylation DNA Damage Response Regulation Of Mitotic Cell Cycle Cell Population Proliferation Replication Fork Processing Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Nucleus Localization Regulation Of Cell Cycle Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin Transcription Elongation-coupled Chromatin Remodeling Transcription Pausing By RNA Polymerase II	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing In Utero Embryonic Development Blastocyst Growth DNA Repair Double-strand Break Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neuroblast Proliferation Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Telomere Maintenance In Response To DNA Damage Mitotic G2/M Transition Checkpoint Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Regulation Of Cell Cycle R-loop Processing Protein K63-linked Ubiquitination T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Alvocidib Seliciclib Trilaciclib Zotiraciclib
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Body mass index ( 26426971)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		60 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CEBPA CTDP1 CTDSPL CUL1 DHX30 EAF1 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST LBX2 MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 OGT PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 STUB1 SUPT5H TAF7 TARBP2 TP53 TRAF2 UBE2A ZMYM6	35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NABP2 NAT2 NCL PRKDC RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5
Entrez ID		1025	4683
HPRD ID		16016	04050
Ensembl ID		ENSG00000136807	ENSG00000104320
Uniprot IDs		P50750	A0A0C4DG07 O60934
PDB IDs		3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R	5WQD 7SID 8BAH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Protein Modification Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process RNA Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Negative Regulation Of DNA-templated Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signal Transduction	DNA Damage Response DNA Metabolic Process DNA Repair Double-strand Break Repair Response To Ionizing Radiation Nucleoplasm Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Recombination Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Response To Radiation Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Recombinational Repair Regulation Of Double-strand Break Repair Telomere Maintenance Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Telomere Organization Chromosome Nucleobase-containing Compound Metabolic Process Chromatin Organization Double-strand Break Repair Via Homologous Recombination Response To Gamma Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Site Of Double-strand Break Cellular Response To Ionizing Radiation Positive Regulation Of DNA Repair Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Organization Involved In Meiotic Cell Cycle Chromatin Remodeling Cellular Response To Gamma Radiation Positive Regulation Of Double-strand Break Repair DNA Binding Regulation Of Primary Metabolic Process
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