MKNK2 and MESD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MKNK2	MESD
Description		MAPK interacting serine/threonine kinase 2	mesoderm development LRP chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body	Endoplasmic Reticulum Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Apoptotic Process Cell Surface Receptor Signaling Pathway Hemopoiesis Intracellular Signal Transduction Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Protein Localization To Cell Surface Protein Localization To Plasma Membrane Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Nonsyndromic cleft lip with or without cleft palate ( 28087736)
Interacting Genes		13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1	78 interacting genes: - ABCG8 ABITRAM ACBD7 AKIRIN2 AKNAD1 AKT1 APP ARB2A ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KLHL20 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MAPDA MCM9 MELTF MKNK2 MRM1 MTNR1A NAA35 NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SLC6A20 SMARCB1 SNX5 SNX7 TEKTL1 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844
Entrez ID		2872	23184
HPRD ID		05459	12129
Ensembl ID		ENSG00000099875	ENSG00000117899
Uniprot IDs		B3KS07 Q9HBH9	Q14696
PDB IDs		2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR 8P9B 8XFM 9HRC
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Nuclear Estrogen Receptor Activity Enzyme Binding Cellular Response To Lipid Response To Lipid Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Nutrient Levels Cellular Response To Oxygen-containing Compound MAPK Cascade Energy Homeostasis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Nutrient Levels Estrogen Response Element Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Eukaryotic Translation Initiation Factor 4F Complex Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Cullin-RING Ubiquitin Ligase Complex Nucleus Negative Regulation Of Autophagy Mammary Gland Epithelial Cell Proliferation Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Cytosol Nuclear Steroid Receptor Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Catabolic Process Regulation Of Autophagy Estrogen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process P38MAPK Cascade Mitotic Cell Cycle Phase Transition Response To UV Steroid Binding Regulation Of Inflammatory Response Cell Cycle Phase Transition Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Behavioral Fear Response Behavioral Defense Response Cellular Response To Estradiol Stimulus Cellular Response To Starvation Regulation Of MRNA Stability Macromolecule Metabolic Process	Protein Binding Proton-transporting Two-sector ATPase Complex, Catalytic Domain
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