MKNK2

Description		MAPK interacting serine/threonine kinase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Translation Protein Phosphorylation Apoptotic Process Cell Surface Receptor Signaling Pathway Hemopoiesis Intracellular Signal Transduction Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Nonsyndromic cleft lip with or without cleft palate ( 28087736)
Interacting Genes		13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1
Entrez ID		2872
HPRD ID		05459
Ensembl ID		ENSG00000099875
Uniprot IDs		B3KS07 Q9HBH9
PDB IDs		2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR 8P9B 8XFM 9HRC
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Nuclear Estrogen Receptor Activity Enzyme Binding Cellular Response To Lipid Response To Lipid Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Nutrient Levels Cellular Response To Oxygen-containing Compound MAPK Cascade Energy Homeostasis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Nutrient Levels Estrogen Response Element Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Eukaryotic Translation Initiation Factor 4F Complex Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Cullin-RING Ubiquitin Ligase Complex Nucleus Negative Regulation Of Autophagy Mammary Gland Epithelial Cell Proliferation Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Cytosol Nuclear Steroid Receptor Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Catabolic Process Regulation Of Autophagy Estrogen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process P38MAPK Cascade Mitotic Cell Cycle Phase Transition Response To UV Steroid Binding Regulation Of Inflammatory Response Cell Cycle Phase Transition Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Behavioral Fear Response Behavioral Defense Response Cellular Response To Estradiol Stimulus Cellular Response To Starvation Regulation Of MRNA Stability Macromolecule Metabolic Process
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