MKNK2 and EIF4G1

Number of citations of the paper that reports this interaction (PMID 12897141)
21

Data Source:
BioGRID (enzymatic study)

		MKNK2	EIF4G1
Gene Name		MAP kinase interacting serine/threonine kinase 2	eukaryotic translation initiation factor 4 gamma, 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Cell Surface Receptor Signaling Pathway Hemopoiesis Intracellular Signal Transduction Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process
Pathways			Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 RBX1 RPL7A VBP1	24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		2872	1981
HPRD ID		05459	06774
Ensembl ID		ENSG00000099875	ENSG00000114867
Uniprot IDs		B3KS07 Q9HBH9	B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65
PDB IDs		2AC3 2AC5 2HW7	1LJ2 1UG3 2W97 4F02
Enriched GO Terms of Interacting Partners?		Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Lipid Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Hormone Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 4 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Metabolic Process Toll-like Receptor Signaling Pathway Vagina Development Uterus Development Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Response To Lipid Cellular Macromolecule Catabolic Process Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Intracellular Estrogen Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Activation Of Innate Immune Response Response To Hormone Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Insulin Receptor Signaling Pathway Female Genitalia Development Mammary Gland Epithelial Cell Proliferation Apoptotic Process Cellular Response To Lipopolysaccharide Signal Transduction MRNA Catabolic Process Cellular Response To Molecule Of Bacterial Origin Response To Peptide Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Death Nuclear-transcribed MRNA Poly(A) Tail Shortening Death	Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing
Tagcloud ?		2b 4g au characterised comprise dfd dfg differ eif4e export importin inserts integrating lacks map mknk1 mnk mnk1a mnk2a mnks mrnas polybasic possesses scaffold share subcellular symbols termini unusual	bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights
Tagcloud (Difference) ?		2b 4g au characterised comprise dfd dfg differ eif4e export importin inserts integrating lacks map mknk1 mnk mnk1a mnk2a mnks mrnas polybasic possesses scaffold share subcellular symbols termini unusual	bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights
Tagcloud (Intersection) ?