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HSD17B10 and UBE2D1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
HSD17B10
UBE2D1
Description
hydroxysteroid 17-beta dehydrogenase 10
ubiquitin conjugating enzyme E2 D1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
TRNA Methyltransferase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
TRNA Binding
RNA Binding
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity
Protein Binding
Cholate 7-alpha-dehydrogenase (NAD+) Activity
Oxidoreductase Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
L-isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
TRNA Processing
Steroid Metabolic Process
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Polyubiquitination
Negative Regulation Of TORC1 Signaling
Pathways
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
Mitochondrial protein degradation
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
Diseases
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
GWAS
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Interacting Genes
30 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHB
PDHX
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARK2C
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
CUL4A
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL2
FBXL20
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HECTD1
HECW1
HERC2
HERC3
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KEAP1
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MIB2
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NQO1
NR1H2
OBI1
PELI1
PJA2
PMAIP1
POLL
POLM
POLR2E
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF207
RNF216
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SPOP
STAM2
STUB1
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM21
TRIM22
TRIM23
TRIM24
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM72
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBR5
UBTD1
UFM1
UHRF1
UHRF2
USP21
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
ZRANB1
Entrez ID
3028
7321
HPRD ID
02223
04267
Ensembl ID
ENSG00000072506
ENSG00000072401
Uniprot IDs
A0A0S2Z410
Q99714
A0A087WW00
P51668
PDB IDs
1SO8
1U7T
2O23
7ONU
8CBK
8CBL
8CBM
8CBO
8RR1
8RR3
8RR4
9EY0
9EY1
9EY2
9GCH
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
7ZJ3
Enriched GO Terms of Interacting Partners
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Mitochondrion
Organic Acid Metabolic Process
Carboxylic Acid Metabolic Process
Small Molecule Metabolic Process
Mitochondrial Matrix
TOM Complex
Tricarboxylic Acid Cycle
Mitochondrial Outer Membrane Translocase Complex
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
CD40 Receptor Complex
Protein Insertion Into Mitochondrial Outer Membrane
Catabolic Process
Carboxylic Acid Catabolic Process
Organophosphate Metabolic Process
Oxidoreductase Activity
Glutamine Metabolic Process
Pyruvate Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex
Mitochondrial Inner Membrane
Protein Import Into Mitochondrial Matrix
Lipid Metabolic Process
Monocarboxylic Acid Metabolic Process
Protein Transmembrane Transporter Activity
Generation Of Precursor Metabolites And Energy
Purine-containing Compound Metabolic Process
Catalytic Activity
Dicarboxylic Acid Metabolic Process
Protein Targeting To Mitochondrion
Acyl-CoA Metabolic Process
Acetyl-CoA Metabolic Process
Protein Insertion Into Mitochondrial Membrane
Establishment Of Protein Localization To Mitochondrial Membrane
Ketone Body Biosynthetic Process
Mitochondrion Targeting Sequence Binding
Organophosphate Biosynthetic Process
Cytoplasmic Side Of Plasma Membrane
Nucleoside Phosphate Metabolic Process
Acetyl-CoA C-acetyltransferase Activity
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Interleukin-17A-mediated Signaling Pathway
Protein Localization To Mitochondrion
Neuron Projection Organization
Enoyl-CoA Hydratase Activity
Pyruvate Decarboxylation To Acetyl-CoA
Sulfur Compound Metabolic Process
Midgut Development
Mitochondrial Nucleoid
L-glutamate Catabolic Process
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Macromolecule Catabolic Process
Zinc Ion Binding
Macromolecule Metabolic Process
Proteolysis
Catabolic Process
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Metal Ion Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Cytoplasm
Protein Monoubiquitination
Response To Stress
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Post-translational Protein Modification
Cytosol
Immune System Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
DNA Damage Response
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Binding
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Tagcloud (Intersection)
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