HSD17B10 and HMGCL

Number of citations of the paper that reports this interaction (PubMedID 22496890)
28

Data Source:
BioGRID (two hybrid)

		HSD17B10	HMGCL
Description		hydroxysteroid 17-beta dehydrogenase 10	3-hydroxy-3-methylglutaryl-CoA lyase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	TRNA Binding RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Cholate 7-alpha-dehydrogenase (NAD+) Activity Oxidoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Magnesium Ion Binding Catalytic Activity Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Lyase Activity Oxo-acid-lyase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization TRNA Processing Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	L-leucine Catabolic Process Lipid Metabolic Process Mitochondrion Organization Ketone Body Biosynthetic Process
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation	Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids	3-hydroxyglutaric acid
Diseases		Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency	3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)	High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		30 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHB PDHX PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	12 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 IKBKB MS4A7 NEDD4 PEX5 RNF126 UBC
Entrez ID		3028	3155
HPRD ID		02223	02003
Ensembl ID		ENSG00000072506	ENSG00000117305
Uniprot IDs		A0A0S2Z410 Q99714	P35914
PDB IDs		1SO8 1U7T 2O23 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH	2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?		Mitochondrion Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Mitochondrial Matrix TOM Complex Tricarboxylic Acid Cycle Mitochondrial Outer Membrane Translocase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Protein Insertion Into Mitochondrial Outer Membrane Catabolic Process Carboxylic Acid Catabolic Process Organophosphate Metabolic Process Oxidoreductase Activity Glutamine Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Inner Membrane Protein Import Into Mitochondrial Matrix Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Protein Transmembrane Transporter Activity Generation Of Precursor Metabolites And Energy Purine-containing Compound Metabolic Process Catalytic Activity Dicarboxylic Acid Metabolic Process Protein Targeting To Mitochondrion Acyl-CoA Metabolic Process Acetyl-CoA Metabolic Process Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Ketone Body Biosynthetic Process Mitochondrion Targeting Sequence Binding Organophosphate Biosynthetic Process Cytoplasmic Side Of Plasma Membrane Nucleoside Phosphate Metabolic Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Interleukin-17A-mediated Signaling Pathway Protein Localization To Mitochondrion Neuron Projection Organization Enoyl-CoA Hydratase Activity Pyruvate Decarboxylation To Acetyl-CoA Sulfur Compound Metabolic Process Midgut Development Mitochondrial Nucleoid L-glutamate Catabolic Process	Protein Monoubiquitination Tat Protein Binding Positive Regulation Of DNA Binding Cerebral Cortex Neuron Differentiation Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Modification Process Transcriptional Start Site Selection At RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Forebrain Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Post-translational Protein Modification Protein Targeting Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Fatty Acid Beta-oxidation Transcription Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding Germinal Vesicle Protein-containing Complex Organization Protein-containing Complex Assembly RNA Polymerase II Core Complex Assembly Protein Metabolic Process Lipid Oxidation 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Fatty Acid Catabolic Process Mitochondrial Ribonuclease P Complex Fatty Acid Oxidation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing Protein Tetramerization Protein-folding Chaperone Binding Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Blood Vessel Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
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