HSD17B10 and FAF1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HSD17B10	FAF1
Gene Name		hydroxysteroid (17-beta) dehydrogenase 10	Fas (TNFRSF6) associated factor 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Poly(A) RNA Binding 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Lipid Metabolic Process TRNA Processing Branched-chain Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Branched-chain amino acid catabolism Metabolism of amino acids and derivatives
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases
GWAS			Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)
Protein-Protein Interactions		5 interactors: APP CHD3 FAF1 HTRA2 UBE2D1	37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB
Entrez ID		3028	11124
HPRD ID		02223	05124
Ensembl ID		ENSG00000072506	ENSG00000185104
Uniprot IDs		Q99714	B4DEJ6 Q9UNN5
PDB IDs		1F67 1SO8 1U7T 2O23	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Multicellular Organism Growth Pentacyclic Triterpenoid Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Cellular Macromolecule Catabolic Process Regulation Of Catalytic Activity Adult Behavior Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Locomotory Behavior Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Regulation Of Developmental Growth Neuron Remodeling Response To Herbicide Protein Autoprocessing Regulation Of Mitochondrion Degradation Negative Regulation Of Proteolysis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Peptidase Activity	Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway
Tagcloud ?		10c 17beta abad abnormally abound allopregnanolone alternate avenue belief catalyzes dehydrogenase homotetrameric hydroxysteroid infantile isoleucine misconceptions misnomer missense mistaken multifunctional negligible neuroactive opened predicated properly psychomotor steroids xp11	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Difference) ?		10c 17beta abad abnormally abound allopregnanolone alternate avenue belief catalyzes dehydrogenase homotetrameric hydroxysteroid infantile isoleucine misconceptions misnomer missense mistaken multifunctional negligible neuroactive opened predicated properly psychomotor steroids xp11	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Intersection) ?