HSD17B10 and TRAF3IP2

Number of citations of the paper that reports this interaction (PubMedID 22496890)
28

Data Source:
BioGRID (two hybrid)

		HSD17B10	TRAF3IP2
Description		hydroxysteroid 17-beta dehydrogenase 10	TRAF3 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex	Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	TRNA Binding RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Cholate 7-alpha-dehydrogenase (NAD+) Activity Oxidoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Signaling Receptor Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization TRNA Processing Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Protein Polyubiquitination Establishment Of T Cell Polarity B Cell Homeostasis B Cell Apoptotic Process Kidney Development Positive Regulation Of Defense Response To Virus By Host Leukocyte Activation Involved In Inflammatory Response Transitional Two Stage B Cell Differentiation B Cell Affinity Maturation Eosinophil Mediated Immunity Protein Import Into Nucleus Inflammatory Response Immune Response Humoral Immune Response Heart Development Response To Xenobiotic Stimulus Gene Expression Protein Ubiquitination Cytokine-mediated Signaling Pathway B Cell Mediated Immunity Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway T Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Protein Localization To Nucleus Intracellular Signal Transduction Interleukin-17A-mediated Signaling Pathway Type 2 Immune Response T Cell Activation Neutrophil Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Skin Development MRNA Stabilization Lymph Node Development Spleen Development Mucus Secretion Protein K63-linked Ubiquitination Cellular Response To Cytokine Stimulus T-helper 17 Type Immune Response Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Protein Localization To P-body Negative Regulation Of Interleukin-17-mediated Signaling Pathway Eosinophil Homeostasis
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases		Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)	Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Psoriasis ( 20953188 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 20953186 26626624) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		30 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHB PDHX PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	23 interacting genes: CD40 CHUK FHL3 GOLGA2 HSD17B10 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 TRIP6 UBC UBE2V1
Entrez ID		3028	10758
HPRD ID		02223	06129
Ensembl ID		ENSG00000072506	ENSG00000056972
Uniprot IDs		A0A0S2Z410 Q99714	O43734
PDB IDs		1SO8 1U7T 2O23 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH
Enriched GO Terms of Interacting Partners?		Mitochondrion Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Mitochondrial Matrix TOM Complex Tricarboxylic Acid Cycle Mitochondrial Outer Membrane Translocase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Protein Insertion Into Mitochondrial Outer Membrane Catabolic Process Carboxylic Acid Catabolic Process Organophosphate Metabolic Process Oxidoreductase Activity Glutamine Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Inner Membrane Protein Import Into Mitochondrial Matrix Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Protein Transmembrane Transporter Activity Generation Of Precursor Metabolites And Energy Purine-containing Compound Metabolic Process Catalytic Activity Dicarboxylic Acid Metabolic Process Protein Targeting To Mitochondrion Acyl-CoA Metabolic Process Acetyl-CoA Metabolic Process Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Ketone Body Biosynthetic Process Mitochondrion Targeting Sequence Binding Organophosphate Biosynthetic Process Cytoplasmic Side Of Plasma Membrane Nucleoside Phosphate Metabolic Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Interleukin-17A-mediated Signaling Pathway Protein Localization To Mitochondrion Neuron Projection Organization Enoyl-CoA Hydratase Activity Pyruvate Decarboxylation To Acetyl-CoA Sulfur Compound Metabolic Process Midgut Development Mitochondrial Nucleoid L-glutamate Catabolic Process	CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor Receptor Binding Thioesterase Binding TRIF-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Signal Transduction Involved In Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytoplasmic Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Other Organism Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Innate Immune Response IkappaB Kinase Complex Positive Regulation Of Immune Response Immune Response Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Defense Response To Symbiont Interleukin-17-mediated Signaling Pathway Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Transferrin Receptor Binding Defense Response Positive Regulation Of JUN Kinase Activity Toll-like Receptor Signaling Pathway Response To Virus Regulation Of Signal Transduction Identical Protein Binding
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