HSD17B10 and CPS1

Number of citations: 28 (PubMedID 22496890)
Data Source: BioGRID (two hybrid)

		HSD17B10	CPS1
Name		hydroxysteroid 17-beta dehydrogenase 10	carbamoyl-phosphate synthase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Plasma Membrane Membrane Protein-containing Complex Mitochondrial Nucleoid
	Molecular Function	TRNA Binding RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Cholate 7-alpha-dehydrogenase (NAD+) Activity Oxidoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Nucleotide Binding Catalytic Activity Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Endopeptidase Activity Calcium Ion Binding Protein Binding ATP Binding Phospholipid Binding Glutamate Binding Ligase Activity Potassium Ion Binding Small Molecule Binding Protein-containing Complex Binding Metal Ion Binding Modified Amino Acid Binding
	Biological Process	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization TRNA Processing Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Urea Cycle Liver Development 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Glutamine Metabolic Process Midgut Development Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Amine Citrulline Biosynthetic Process Triglyceride Catabolic Process Response To Food Response To Lipopolysaccharide Response To Glucagon Response To Oleic Acid Vasodilation Response To Starvation Response To Amino Acid Cellular Response To Fibroblast Growth Factor Stimulus Nitric Oxide Metabolic Process Response To Steroid Hormone Homocysteine Metabolic Process Response To Glucocorticoid Response To CAMP Monoatomic Anion Homeostasis Response To Growth Hormone Hepatocyte Differentiation Carbamoyl Phosphate Biosynthetic Process Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Response To Dexamethasone Response To Alcohol
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation	Urea cycle
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids	Carglumic acid
Diseases		Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency	Carbamoyl phosphate synthetase I deficiency
GWAS		Bipolar disorder ( 31043756 ) Body mass index ( 28892062 )	Alanine aminotransferase levels ( 33547301 33339817 ) Alanine transaminase levels ( 29403010 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Betaine levels in individuals undergoing cardiac evaluation ( 26822151 ) Blood urea nitrogen levels ( 31152163 ) Body mass index ( 25673413 26426971 ) Body mass index in asthmatics ( 23517042 ) Chronic kidney disease ( 20383146 31152163 26831199 ) Creatinine levels ( 31015462 29403010 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Estimated glomerular filtration rate ( 31152163 31451708 31015462 30604766 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fibrinogen ( 20031577 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Glycine levels ( 31070104 30837465 ) HDL cholesterol ( 24097068 ) HDL cholesterol levels ( 32203549 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Homocysteine levels ( 20154341 23824729 ) Lipoprotein (a) levels ( 33730874 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 32888494 ) Macular telangiectasia type 2 ( 33654266 28250457 ) Mean corpuscular hemoglobin ( 27863252 29403010 32888494 ) Mean corpuscular volume ( 27863252 29403010 32888494 ) Mean platelet volume ( 27863252 32888494 ) Metabolic traits ( 21886157 ) Metabolite levels ( 31628463 23378610 ) Neutrophil count ( 32888494 ) Non-small cell lung cancer ( 23144319 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Plasma homocysteine levels (post-methionine load test) ( 24651765 ) Platelet count ( 32888494 27863252 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 27863252 ) Positive urgency ( 30718321 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 24625756 25569235 33031748 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Serum uric acid levels ( 30993211 ) Systolic blood pressure ( 30224653 ) Urate levels ( 31578528 ) Urate levels in obese individuals ( 25811787 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31630189 31511532 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites ( 26352407 ) Urinary potassium to creatinine ratio ( 30910378 ) Urinary sodium to creatinine ratio ( 30910378 ) White blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: KDM6A	2 novel interactors: ATIC NCOA1
Interacting Genes		30 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHB PDHX PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	3 interacting genes: ARAF HSD17B10 RAF1
Entrez ID		3028	1373
HPRD ID		02223	01995
Ensembl ID		ENSG00000072506	ENSG00000021826
Uniprot IDs		A0A0S2Z410 Q99714	P31327 Q6PEK7
PDB IDs		1SO8 1U7T 2O23 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH	2YVQ 4UTR 4UTV 4UTX 4UTZ 4UU7 4UU8 4UUA 4UUB 5DOT 5DOU 5OJO 6UEL 6W2J
GO Terms Enriched among Interactors		Mitochondrion Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Mitochondrial Matrix TOM Complex Tricarboxylic Acid Cycle Mitochondrial Outer Membrane Translocase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Protein Insertion Into Mitochondrial Outer Membrane Catabolic Process Carboxylic Acid Catabolic Process Organophosphate Metabolic Process Oxidoreductase Activity Glutamine Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Inner Membrane Protein Import Into Mitochondrial Matrix Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Protein Transmembrane Transporter Activity Generation Of Precursor Metabolites And Energy Purine-containing Compound Metabolic Process Catalytic Activity Dicarboxylic Acid Metabolic Process Protein Targeting To Mitochondrion Acyl-CoA Metabolic Process Acetyl-CoA Metabolic Process Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Ketone Body Biosynthetic Process Mitochondrion Targeting Sequence Binding Organophosphate Biosynthetic Process Cytoplasmic Side Of Plasma Membrane Nucleoside Phosphate Metabolic Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Interleukin-17A-mediated Signaling Pathway Protein Localization To Mitochondrion Neuron Projection Organization Enoyl-CoA Hydratase Activity Pyruvate Decarboxylation To Acetyl-CoA Sulfur Compound Metabolic Process Midgut Development Mitochondrial Nucleoid L-glutamate Catabolic Process	MAP Kinase Kinase Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Cerebellum Development Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Cerebral Cortex Development IMP Cyclohydrolase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Transferase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Death-inducing Signaling Complex Assembly Labyrinthine Layer Morphogenesis Dihydrofolate Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Female Receptivity Mitochondrial RNA 5'-end Processing MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Brainstem Development 'de Novo' IMP Biosynthetic Process Tetrahydrofolate Biosynthetic Process 'de Novo' AMP Biosynthetic Process 'de Novo' XMP Biosynthetic Process TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity TRNA 3'-end Processing Isoleucine Metabolic Process L-isoleucine Catabolic Process (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Adenylate Cyclase Activator Activity Response To Thyroglobulin Triiodothyronine Regulation Of Female Receptivity Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Female Mating Behavior Carbon Catabolite Regulation Of Transcription Folic Acid-containing Compound Biosynthetic Process