FRAT2 and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		FRAT2	PTPN12
Description		FRAT regulator of Wnt signaling pathway 2	protein tyrosine phosphatase non-receptor type 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection Anchoring Junction
	Molecular Function		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding
	Biological Process	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs			Tiludronic acid
Diseases
GWAS		Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte count ( 32888494)	A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte count ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12	57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		23401	5782
HPRD ID		05419	02513
Ensembl ID		ENSG00000181274	ENSG00000127947
Uniprot IDs		O75474	B4E105 Q05209
PDB IDs			5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?		Chiasma Intracellular Signal Transduction Negative Regulation Of Cell Differentiation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Mismatch Repair Complex Response To Epidermal Growth Factor Negative Regulation Of Immature T Cell Proliferation Intracellular Signaling Cassette ERBB2-EGFR Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of T Cell Differentiation In Thymus Ras Protein Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Cell Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mismatched DNA Binding Signal Transduction Regulation Of Cell Population Proliferation Nucleotide Binding Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Synaptonemal Complex Regulation Of Cell Development Regulation Of Protein Localization To Nucleus Focal Adhesion ATP Binding Reciprocal Meiotic Recombination Regulation Of Signal Transduction NF-kappaB Binding Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Mismatch Repair Condensed Chromosome Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cytosol Regulation Of Cell Differentiation	Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Kinase Activity Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Signal Transduction Phosphorylation Receptor Complex Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Phosphate Metabolic Process Perinuclear Region Of Cytoplasm Response To Growth Factor Positive Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Animal Organ Development Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion Insulin Receptor Substrate Binding Positive Regulation Of Protein Phosphorylation Anchoring Junction Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphorylation Regulation Of Cell Motility Positive Regulation Of Developmental Process
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